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Start Over Author "Achilli, L" Journal journal of organic chemistry

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1. A substructure approach toward polymeric receptors targeting dihydrofolate reductase inhibitors. 2. Molecularly imprinted polymers against Z-l-glutamic acid showing affinity for larger molecules.

Author

Hall AJ, Achilli L, Manesiotis P, Quaglia M, De Lorenzi E, and Sellergren B

Subjects
Folic Acid Antagonists pharmacology, Magnetic Resonance Spectroscopy, Methotrexate pharmacology, Enzyme Inhibitors chemistry, Folic Acid Antagonists chemistry, Glutamic Acid chemistry, Methotrexate chemistry, Polymers chemistry, Tetrahydrofolate Dehydrogenase drug effects
Abstract

The preparation of a molecularly imprinted polymer against N-Z-L-glutamic acid using a novel bis-urea functional monomer is described. The polymer exhibits affinity for the template over N-Z-protected aspartic acid and glycine and, further, is capable of binding larger molecules, e.g., the anti-cancer drug methotrexate, containing the glutamate substructure.

Published
2003
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