1. Colonization of the oral cavity by yeasts in patients with chronic renal failure undergoing hemodialysis
- Author
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Adriana Fiorini, Cristiane Suemi Shinobu-Mesquita, Sandra Sayuri Nakamura, Terezinha Inez Estivalet Svidzinski, Patrícia de Souza Bonfim-Mendonça, Janine Silva Ribeiro Godoy, Neli Pieralisi, and Sérgio Seiji Yamada
- Subjects
Male ,Nystatin ,Cancer Research ,Antifungal Agents ,Time Factors ,medicine.medical_treatment ,Colony Count, Microbial ,Candida glabrata ,Gastroenterology ,Echinocandins ,chemistry.chemical_compound ,Caspofungin ,Amphotericin B ,Candida albicans ,Fluconazole ,Candida ,Aged, 80 and over ,biology ,Middle Aged ,Phenotype ,Hypertension ,Periodontics ,Female ,Hemodialysis ,Oral Surgery ,medicine.drug ,Adult ,medicine.medical_specialty ,Microbial Sensitivity Tests ,Mycology ,Pathology and Forensic Medicine ,Microbiology ,Diabetes Complications ,Lipopeptides ,Renal Dialysis ,Internal medicine ,medicine ,Humans ,Candida tropicalis ,Dentures ,Aged ,Voriconazole ,Mouth ,Triazoles ,biology.organism_classification ,Pyrimidines ,Otorhinolaryngology ,chemistry ,Kidney Failure, Chronic - Abstract
Objectives To determine the frequency of yeast in the oral cavity of patients with chronic renal failure, undergoing hemodialysis (PCRFH); identification and antifungal susceptibility profile of yeast and demographic profile of patients. Methods We performed mouthwash in 146 PCRFH; the rinse fluid was collected and cultured, yeasts grown were identified by phenotypic and molecular methods. The antifungal susceptibility profile was determined against nystatin, amphotericin B, fluconazole, voriconazole, and caspofungin based in Clinical and Laboratory Standards Institute (document M27-A3). Results Positive culture was observed in 39% of patients, of whom 53% were women; the median of dialysis time was 2.9 years. The age of the colonized patients varied between 26 and 84 years, with a median of 52.5 years. PCRFH over 45 years were significantly more colonized (P = 0.0108) as well as denture wearers (84.0%). We isolated 81 yeasts, predominantly Candida albicans (63%) followed by Candida glabrata. In general, yeasts were sensitive to the evaluated antifungal agents, but there was significant variation in the minimum inhibitory concentration, especially among non-C. albicans Candida (NCAC) compared to fluconazole, caspofungin, and amphotericin B. NCAC required significantly higher concentrations of fluconazole (P
- Published
- 2012
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