1. Calcitonin gene-related peptide levels in saliva of patients with burning mouth syndrome
- Author
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József Németh, János Tajti, Radmila Obrenovic, Jasna Zidverc-Trajkovic, Nadezda Sternic, Milija Mijajlovic, János Gardi, Dragan Stanimirovic, László Vécsei, and Ljiljana Janković
- Subjects
Cancer Research ,medicine.medical_specialty ,Saliva ,education ,Calcitonin gene-related peptide ,Pathology and Forensic Medicine ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Medicine ,Basal ganglia disease ,Burning Sensation ,Trigeminal nerve ,business.industry ,digestive, oral, and skin physiology ,030206 dentistry ,Burning mouth syndrome ,medicine.disease ,stomatognathic diseases ,Endocrinology ,Otorhinolaryngology ,Calcitonin ,Periodontics ,Oral Surgery ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Burning mouth syndrome (BMS) is an intraoral burning sensation for which no medical or dental cause can be found. Recent studies suggest that primary neuropathic dysfunction might be involved in the pathogenesis of BMS. Calcitonin gene-related peptide (CGRP) plays an important role in the development of pain and serves as a biological marker of trigeminovascular activation. The aim of this study was to determine the levels of CGRP in the saliva of BMS patients and estimate the trigeminovascular activation in BMS. CGRP levels were measured, by RIA method in 78 BMS patients and 16 healthy subjects. The levels of CGRP were non-significantly decreased in BMS patients in comparison to healthy subjects. These results suggest that trigeminal nerve degeneration may be the underlying cause of BMS.
- Published
- 2008
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