1. L-theanine suppresses the metastasis of prostate cancer by downregulating MMP9 and Snail.
- Author
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Fan, Xirui, Zhou, Jinyi, Bi, Xiaowen, Liang, Juanjuan, Lu, Shuai, Yan, Xintong, Luo, Lan, and Yin, Zhimin
- Subjects
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PROSTATE cancer , *AMINO acid derivatives , *METASTASIS , *PROMOTERS (Genetics) , *EPIGALLOCATECHIN gallate , *DACARBAZINE , *GLUTAMIC acid metabolism , *GLUTAMIC acid , *BIOCHEMISTRY , *RESEARCH , *ANIMAL experimentation , *RESEARCH methodology , *PROTEOLYTIC enzymes , *ANTINEOPLASTIC agents , *CYTOSKELETAL proteins , *MEDICAL cooperation , *EVALUATION research , *CELL motility , *PHENOMENOLOGY , *CELLULAR signal transduction , *COMPARATIVE studies , *GLYCOPROTEINS , *DNA-binding proteins , *TEA , *PROSTATE tumors , *MICE , *PHARMACODYNAMICS - Abstract
Prostate cancer (PCa) is a very prevalent male-specific malignancy; most PCa patients eventually die as a result of metastasis. L-theanine (C7H14N2O3), a nonprotein amino acid derivative from green tea leaves, has been demonstrated to act as an anticarcinogen through proapoptotic and antiproliferative effects. However, the antimetastatic effect of L-theanine in tumor cells and its underlying mechanism are still unclear. Here, we found that L-theanine could suppress invasion, migration, and increase cell-cell adhesion of prostate cancer cells in vitro and in vivo. We also found that L-theanine could inhibit the epithelial-mesenchymal transition process in PCa. Our study revealed that L-theanine could downregulate MMP9, N-cadherin, Vimentin, Snail, and upregulate E-cadherin. Furthermore, L-theanine suppressed the transcription of MMP9 and Snail by significantly inhibiting the ERK/NF-κB signaling pathway and the binding activity of p65 to the promoter regions of MMP9 and Snail. All of these findings suggest that L-theanine has therapeutic potential for metastatic PCa and may be considered a promising candidate for antimetastatic therapy of prostate cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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