Search

Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and mammalian cells. It was recently recognized to possess multiple biological functions. A striking anticancer effect of IP[sub 6] was demonstrated in different experimental models. Inositol is also a natural constituent possessing moderate anticancer activity. The most consistent and best anticancer results were obtained from the combination of IP[sub 6] plus inositol. In addition to reducing cell proliferation, IP[sub 6] increases differentiation of malignant cells, often resulting in a reversion to normal phenotype. Exogenously administered IP[sub 6] is rapidly taken into the cells and dephosphorylated to lower-phosphate inositol phosphates, which further interfere with signal transduction pathways and cell cycle arrest. Enhanced immunity and antioxidant properties can also contribute to tumor cell destruction. However, the molecular mechanisms underlying this anticancer action are not fully understood. Because it is abundantly present in regular diet, efficiently absorbed from the gastrointestinal tract, and safe, IP[sub 6] holds great promise in our strategies for the prevention and treatment of cancer. IP[sub 6] plus inositol enhances the anticancer effect of conventional chemotherapy, controls cancer metastases, and improves the quality of life, as shown in a pilot clinical trial. The data strongly argue for the use of IP[sub 6] plus inositol in our strategies for cancer prevention and treatment. However, the effectiveness and safety of IP[sub 6] plus inositol at therapeutic doses needs to be determined in phase I and phase II clinical trials in humans. [ABSTRACT FROM AUTHOR]

The article focuses on the 2006 annual International Research Conference on Food, Nutrition, and Cancer sponsored by the American Institute for Cancer Research/World Cancer Research Fund International (AICR/WCRF) in Washington D.C. The conference was attended by nearly 400 people, which was opened by Kathryn Ward, senior vice president of AICR. During the event, a video on the process behind the second Expert Report was shown with evidence linking food, nutrition, and physical activity to the risk of developing cancer.