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Start Over Author "Pfob, A." Journal journal of nuclear medicine
21 results on '"Pfob, A."'

4. First Safety and Efficacy Data with the Radiohybrid177Lu-rhPSMA-10.1 for the Treatment of Metastatic Prostate Cancer

Author

Dierks, Alexander, primary, Gäble, Alexander, additional, Rinscheid, Andreas, additional, Wienand, Georgine, additional, Pfob, Christian H., additional, Kircher, Malte, additional, Enke, Johanna S., additional, Janzen, Tilman, additional, Patt, Marianne, additional, Trepel, Martin, additional, Weckermann, Dorothea, additional, Bundschuh, Ralph A., additional, and Lapa, Constantin, additional

Published
2023
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5. Preclinical Evaluation of Minigastrin Analogs and Proof-of-Concept [68Ga]Ga-DOTA-CCK-66 PET/CT in 2 Patients with Medullary Thyroid Cancer

Author

Günther, Thomas, primary, Holzleitner, Nadine, additional, Viering, Oliver, additional, Beck, Roswitha, additional, Wienand, Georgine, additional, Dierks, Alexander, additional, Pfob, Christian H., additional, Bundschuh, Ralph A., additional, Kircher, Malte, additional, Lapa, Constantin, additional, and Wester, Hans-Jürgen, additional

Published
2023
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6. Long-Term Nephrotoxicity of177Lu-PSMA Radioligand Therapy

Author

Steinhelfer, Lisa, primary, Lunger, Lukas, additional, Cala, Lisena, additional, Pfob, Christian H., additional, Lapa, Constantin, additional, Hartrampf, Philipp E., additional, Buck, Andreas K., additional, Schäfer, Hannah, additional, Schmaderer, Christoph, additional, Tauber, Robert, additional, Brosch-Lenz, Julia, additional, Haller, Bernhard, additional, Meissner, Valentin H., additional, Knorr, Karina, additional, Weber, Wolfgang A., additional, and Eiber, Matthias, additional

Published
2023
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7. An Intrapatient Dosimetry Comparison of177Lu-rhPSMA-10.1 and177Lu-PSMA-I&T in Patients with Metastatic Castration-Resistant Prostate Cancer

Author

Rinscheid, Andreas, primary, Gäble, Alexander, additional, Wienand, Georgine, additional, Pfob, Christian, additional, Dierks, Alexander, additional, Kircher, Malte, additional, Trepel, Martin, additional, Weckermann, Dorothea, additional, Lapa, Constantin, additional, and Bundschuh, Ralph A., additional

Published
2023
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8. C-X-C Motif Chemokine Receptor 4–Directed Scintigraphy of Multiple Myeloma Using [99mTc]Tc-PentixaTec

Author

Enke, Johanna S., primary, Reitsam, Nic G., additional, Grosser, Bianca, additional, Kircher, Malte, additional, Dierks, Alexander, additional, Bundschuh, Ralph A., additional, Wienand, Georgine, additional, Uhrmacher, Luise, additional, Trepel, Martin, additional, Schottelius, Margret, additional, Lapa, Constantin, additional, and Pfob, Christian H., additional

Published
2023
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11. Long-Term Nephrotoxicity of 177Lu-PSMA Radioligand Therapy.

Author

Steinhelfer, Lisa, Lunger, Lukas, Cala, Lisena, Pfob, Christian H., Lapa, Constantin, Hartrampf, Philipp E., Buck, Andreas K., Schäfer, Hannah, Schmaderer, Christoph, Tauber, Robert, Brosch-Lenz, Julia, Haller, Bernhard, Meissner, Valentin H., Knorr, Karina, Weber, Wolfgang A., and Eiber, Matthias

Published
2024
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17. Radiation Dosimetry for177Lu-PSMA I&T in Metastatic Castration-Resistant Prostate Cancer: Absorbed Dose in Normal Organs and Tumor Lesions

Author

Nagara Tamaki, Robert Tauber, Sibylle Ziegler, Wolfgang P. Fendler, Christian H. Pfob, Matthias Eiber, Matthias Heck, Anne Thieme, Margitta Retz, Klemens Scheidhauer, Markus Schwaiger, Ken Herrmann, Shozo Okamoto, Calogero D'Alessandria, Jakob Allmann, Hans-Juergen Wester, and Tobias Maurer

Subjects
Oncology, medicine.medical_specialty, business.industry, Medizin, Pet imaging, Castration resistant, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Absorbed dose, medicine, Dosimetry, Radiology, Nuclear Medicine and imaging, Nuclear medicine, business, Membrane antigen
Abstract

Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy is increasingly used in metastatic castration-resistant prostate cancer. We aimed to estimate the absorbed doses for normal organs and tumor lesions using 177Lu-PSMA IT 0.12 ± 0.06 Gy/GBq for the liver; and 0.55 ± 0.14 Gy/GBq for the parotid, 0.64 ± 0.40 Gy/GBq for the submandibular, and 3.8 ± 1.4 Gy/GBq for the lacrimal glands. Absorbed organ doses were relatively constant among the 4 different cycles. Tumor lesions received a mean absorbed dose per cycle of 3.2 ± 2.6 Gy/GBq (range, 0.22-12 Gy/GBq). Doses to tumor lesions gradually decreased, with 3.5 ± 2.9 Gy/GBq for the first, 3.3 ± 2.5 Gy/GBq for the second, 2.7 ± 2.3 Gy/GBq for the third, and 2.4 ± 2.2 Gy/GBq for the fourth cycle. SUVs of pretherapeutic PET moderately correlated with absorbed dose (r = 0.44, P < 0.001 for SUVmax; r = 0.43, P < 0.001 for SUVmean) and moderately correlated with the change of SUV (r = 0.478, P < 0.001 for SUVmax, and r = 0.50, P < 0.001 for SUVmean). Conclusion: Organ- and tumor-absorbed doses for 177Lu-PSMA I&T are comparable to recent reports and complement these with information on an excellent correlation between the 4 therapy cycles. With the kidneys representing the critical organ, a cumulative activity of 40 GBq of 177Lu-PSMA I&T appears to be safe and justifiable. The correlation between pretherapeutic SUV and absorbed tumor dose emphasizes the need for PSMA-ligand PET imaging for patient selection.

Published
2016
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18. 68Ga-PSMA-11 PET/CT Interobserver Agreement for Prostate Cancer Assessments: An International Multicenter Prospective Study

Author

Fendler, Wolfgang Peter, primary, Calais, Jeremie, additional, Allen-Auerbach, Martin, additional, Bluemel, Christina, additional, Eberhardt, Nina, additional, Emmett, Louise, additional, Gupta, Pawan, additional, Hartenbach, Markus, additional, Hope, Thomas A., additional, Okamoto, Shozo, additional, Pfob, Christian Helmut, additional, Pöppel, Thorsten D., additional, Rischpler, Christoph, additional, Schwarzenböck, Sarah, additional, Stebner, Vanessa, additional, Unterrainer, Marcus, additional, Zacho, Helle D., additional, Maurer, Tobias, additional, Gratzke, Christian, additional, Crispin, Alexander, additional, Czernin, Johannes, additional, Herrmann, Ken, additional, and Eiber, Matthias, additional

Published
2017
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19. Radiation Dosimetry for177Lu-PSMA I&T in Metastatic Castration-Resistant Prostate Cancer: Absorbed Dose in Normal Organs and Tumor Lesions

Author

Okamoto, Shozo, primary, Thieme, Anne, additional, Allmann, Jakob, additional, D’Alessandria, Calogero, additional, Maurer, Tobias, additional, Retz, Margitta, additional, Tauber, Robert, additional, Heck, Matthias M., additional, Wester, Hans-Juergen, additional, Tamaki, Nagara, additional, Fendler, Wolfgang P., additional, Herrmann, Ken, additional, Pfob, Christian H., additional, Scheidhauer, Klemens, additional, Schwaiger, Markus, additional, Ziegler, Sibylle, additional, and Eiber, Matthias, additional

Published
2016
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20. 68Ga-PSMA-11 PET/CT Interobserver Agreement for Prostate Cancer Assessments: An International Multicenter Prospective Study.

Author

Fendler, Wolfgang Peter, Calais, Jeremie, Allen-Auerbach, Martin, Bluemel, Christina, Eberhardt, Nina, Emmett, Louise, Gupta, Pawan, Hartenbach, Markus, Hope, Thomas A., Okamoto, Shozo, Pfob, Christian Helmut, Pöppel, Thorsten D., Rischpler, Christoph, Schwarzenböck, Sarah, Stebner, Vanessa, Unterrainer, Marcus, Zacho, Helle D., Maurer, Tobias, Gratzke, Christian, and Crispin, Alexander

Published
2017
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21. Radiation Dosimetry for 177Lu-PSMA I&T in Metastatic Castration-Resistant Prostate Cancer: Absorbed Dose in Normal Organs and Tumor Lesions.

Author

Shozo Okamoto, Thieme, Anne, Allmann, Jakob, D’Alessandria, Calogero, Maurer, Tobias, Retz, Margitta, Tauber, Robert, Heck, Matthias M., Wester, Hans-Juergen, Tamaki, Nagara, Fendler, Wolfgang P., Herrmann, Ken, Pfob, Christian H., Scheidhauer, Klemens, Schwaiger, Markus, Ziegler, Sibylle, and Eiber, Matthias

Published
2017
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