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Your search keyword '"Ian P. Clements"' showing total 16 results
Start Over Author "Ian P. Clements" Journal journal of nuclear cardiology
16 results on '"Ian P. Clements"'

1. Quantitative iodine-123-metaiodobenzylguanidine (MIBG) SPECT imaging in heart failure with left ventricular systolic dysfunction: Development and validation of automated procedures in conjunction with technetium-99m tetrofosmin myocardial perfusion SPECT

Author

Ernest V. Garcia, Ji Chen, Arnold F. Jacobson, Ian P. Clements, Russell D. Folks, and Javed Butler

Subjects
Adult, Male, medicine.medical_specialty, Perfusion scanning, 030204 cardiovascular system & hematology, computer.software_genre, 3-Iodobenzylguanidine, Multimodal Imaging, Sensitivity and Specificity, Pattern Recognition, Automated, 030218 nuclear medicine & medical imaging, Machine Learning, Ventricular Dysfunction, Left, 03 medical and health sciences, Organophosphorus Compounds, 0302 clinical medicine, Voxel, Internal medicine, Spect imaging, Image Interpretation, Computer-Assisted, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Aged, 80 and over, Heart Failure, Tomography, Emission-Computed, Single-Photon, business.industry, Reproducibility of Results, Stroke Volume, Organotechnetium Compounds, Stroke volume, Middle Aged, Image Enhancement, medicine.disease, Heart failure, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Perfusion, Technetium-99m-tetrofosmin, computer
Abstract

The purpose of this study was to develop and validate new approaches to quantitative MIBG myocardial SPECT imaging in heart failure (HF) subjects. Quantitative MIBG myocardial SPECT analysis methods, alone and in conjunction with 99mTc-tetrofosmin perfusion SPECT, were adapted from previously validated techniques for the analysis of SPECT and PET perfusion imaging. To account for underestimation of MIBG defect severity in subjects with global reduction in uptake, a mixed reference database based on planar heart/mediastinum (H/M) ratio categories was used. Extent and severity of voxel-based defects and number of myocardial segments with significant dysinnervation (derived score ≥2) were determined. MIBG/99mTc-tetrofosmin mismatch was quantified using regions with preserved innervation as the reference for scaling 99mTc-tetrofosmin voxel maps. Quantification techniques were tested on studies of 619 ischemic (I) and 319 non-ischemic (NI) HF subjects. Using all analytical techniques, IHF subjects had significantly greater and more severe MIBG SPECT abnormalities compared with NIHF subjects. Innervation/perfusion mismatches were also larger in IHF subjects. Findings were consistent between voxel- and myocardial-segment-based quantitation methods. Multiple objective methods for quantitation of MIBG SPECT imaging studies provided internally consistent results for distinguishing the different patterns of uptake between IHF and NIHF subjects.

Published
2015
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2. Outcome prediction in heart failure with atrial fibrillation: Relative role of left ventricular ejection fraction and neurohormonal measures

Author

Ian P. Clements, Gregory A. Wiseman, David O. Hodge, and Arnold F. Jacobson

Subjects
Male, medicine.medical_specialty, Time Factors, medicine.drug_class, Ventricular Function, Left, Norepinephrine, Internal medicine, Atrial Fibrillation, Natriuretic Peptide, Brain, medicine, Natriuretic peptide, Humans, Radiology, Nuclear Medicine and imaging, Sinus rhythm, Hormone metabolism, Prospective Studies, cardiovascular diseases, Aged, Proportional Hazards Models, Heart Failure, Ejection fraction, business.industry, Hazard ratio, Arrhythmias, Cardiac, Stroke Volume, Atrial fibrillation, Stroke volume, Middle Aged, medicine.disease, Hormones, 3-Iodobenzylguanidine, Treatment Outcome, Echocardiography, Heart failure, cardiovascular system, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

Since atrial fibrillation (AF) impacts the measurement and interpretation of left ventricular ejection fraction (LVEF), we hypothesized that the outcome in heart failure (HF) with AF and LVEF ≤ 35% would be more strongly associated with neurohormonal measures than LVEF. Cardiac adverse events [CAE; HF progression (HFP), life-threatening arrhythmia (ARR), and cardiac death (CD)] and all-cause mortality (ACM) were recorded prospectively in 954 patients with HF and LVEF ≤ 35%: 852 in sinus rhythm (SR) and 102 in AF. Cox proportional hazard models found that the univariate hazard ratios (HR) for LVEF and the first CAE (primary outcome), HFP, ARR, CD, and ACM were significant in SR (0.933, P

Published
2013
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3. Symptom improvement after upgrade from right ventricular apical to biventricular pacing: Role of right and left ventricular volumes assessed with single-photon emission computed tomographic equilibrium radionuclide angiocardiography

Author

Ian P. Clements, David O. Hodge, Stuart D. Christenson, Margaret M. Redfield, David L. Hayes, and Brian P. Mullan

Subjects
medicine.medical_specialty, animal structures, Ejection fraction, business.industry, medicine.disease, Single photon emission, Computed tomographic, Symptom improvement, Internal medicine, Heart failure, cardiovascular system, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, In patient, cardiovascular diseases, Cardiology and Cardiovascular Medicine, Ventricular remodeling, business, Radionuclide angiocardiography, circulatory and respiratory physiology
Abstract

Background In patients with heart failure and reduced left ventricular ejection fraction (LVEF), the effect of upgrading from right ventricular (RV) apical to biventricular pacing on RV and left ventricular (LV) volumes and ejection fraction (EF) is unknown. Also, the relationship of symptom improvement after biventricular upgrade to RV and LV volumes and EF has not been clarified.

Published
2010
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4. Assessment of pulmonary thromboendarterectomy by tomographic electrocardiogram-gated equilibrium radionuclide angiocardiography compared with electron beam computed tomography

Author

Ian P. Clements, Jerome F. Breen, Christopher G.A. McGregor, Brian P. Mullan, and Michael K. O'Connor

Subjects
Adult, Male, medicine.medical_specialty, Electron Beam Computed Tomography, Hypertension, Pulmonary, medicine.medical_treatment, Endarterectomy, Pulmonary Artery, Single-photon emission computed tomography, Electrocardiography, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Angiocardiography, Radionuclide angiocardiography, Thrombectomy, Tomography, Emission-Computed, Single-Photon, Ejection fraction, medicine.diagnostic_test, Pulmonary thromboendarterectomy, business.industry, Gated Blood-Pool Imaging, Middle Aged, medicine.disease, Pulmonary hypertension, Cardiology, Female, Pulmonary Embolism, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Gated equilibrium
Abstract

Successful thromboendarterectomy for chronic thromboembolic pulmonary hypertension promptly improves right ventricular (RV) function by decreasing RV volume and increasing ejection fraction (EF). Single photon emission computed tomography (SPECT) equilibrium radionuclide angiocardiography (ERNA) has been validated as a measure of RV and left ventricular (LV) volume and EF.Nine patients with chronic thromboembolic pulmonary hypertension underwent electron beam computed tomography (EBCT) and SPECT ERNA cardiac studies before and after thromboendarterectomy. EBCT and SPECT ERNA measures of RV and LV volume and EF were compared. Before thromboendarterectomy, EBCT and SPECT ERNA RV and LV volumes and RV EF were similar. LV EF was within the normal range with both methods but was slightly greater (P = .004) when measured by EBCT (mean +/- SD, 0.61 +/- 0.08) compared with SPECT ERNA (0.54 +/- 0.10). Thromboendarterectomy measured by EBCT and SPECT ERNA produced marked similar and significant decreases in RV end-systolic (-72 +/- 59 mL vs -58 +/- 25 mL) and end-diastolic (-75 +/- 85 mL vs -76 +/- 32 mL) volumes and similar slight increases in RV EF (0.12 +/- 0.07 vs 0.05 +/- 0.06). Slight decreases in mean LV end-systolic (-19 +/- 23 mL vs -5 +/- 13 mL, P = .05) and end-diastolic (-32 +/- 53 mL vs -9 +/- 31 mL, P = .21) volumes occurred, with little change in mean LV EF (0.05 +/- 0.07 vs 0.00 +/- 0.10).SPECT ERNA is an accurate method for measuring RV and LV volume and EF before and after thromboendarterectomy.

Published
2007
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5. Frequency and determinants of early rapid filling abnormality

Author

Ian P. Clements, David O. Hodge, and Christopher G. Scott

Subjects
Male, medicine.medical_specialty, Digoxin, Minnesota, Diastole, Hemodynamics, Risk Assessment, Sensitivity and Specificity, Ventricular Dysfunction, Left, Age Distribution, Risk Factors, Internal medicine, Heart rate, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Heart Failure, Ejection fraction, business.industry, Incidence, Reproducibility of Results, Gated Blood-Pool Imaging, Stroke Volume, Stroke volume, Middle Aged, Prognosis, medicine.disease, Heart failure, cardiovascular system, Cardiology, Female, Abnormality, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

The frequency and determinants of early rapid diastolic filling abnormalities in the community and in cardiac patients are poorly understood.Early left ventricular (LV) rapid filling was assessed via equilibrium radionuclide angiocardiography in 70 community volunteers (LV ejection fraction [EF]or = 0.50) and 778 cardiac patients, all aged at least 45 years. The frequency of early rapid filling and the independent clinical, therapeutic, and hemodynamic variables predictive of early rapid filling abnormality were determined. Depending on the parameter assessed, early rapid filling was abnormal in 27% to 54% of the community volunteers, 34% to 53% of cardiac patients with an LVEF of 0.50 or greater, and 42% to 67% of cardiac patients with an LVEF lower than 0.50. On the basis of multivariate analysis, models of clinical, therapeutic, and hemodynamic variables were modestly predictive of early rapid filling abnormality. Age, sex, valvular insufficiency, hypertension, digoxin use, and heart rate were independent determinants of early rapid filling.In participants aged older than 44 years, early rapid filling was frequently abnormal in the community volunteers and in patients with an LVEF of 0.50 or greater and was most common in patients with an LVEF lower than 0.50. Clinical, therapeutic, and hemodynamic variables had modest independent predictive value for early rapid filling abnormality.

Published
2006
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6. 24.13: The significance of the method of measurement of left ventricular ejection fraction when considering cardiac resychronization

Author

Stuart D. Christenson, Brian P. Mullan, Ian P. Clements, and David L. Hayes

Subjects
medicine.medical_specialty, Ejection fraction, business.industry, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Session (computer science), Systole, Cardiology and Cardiovascular Medicine, business
Published
2008
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8. 6.2Valvular regurgitation and diastolic function

Author

D.O. Hodge, Christopher G. Scott, and Ian P. Clements

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Cardiology, Medicine, Valvular regurgitation, Radiology, Nuclear Medicine and imaging, Diastolic function, Cardiology and Cardiovascular Medicine, business
Published
2007
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12. Measurement of right and left ventricular ejection fraction and volume with tomographic radionuclide ventriculography: Validation using electron-beam computed tomography

Author

Ian P. Clements, Jerome F. Breen, Michael K. O'Connor, Christopher G.A. McGregor, and Brian P. Mullan

Subjects
Electron Beam Computed Tomography, Ejection fraction, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Radionuclide ventriculography, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Volume (compression)
Published
2005
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13. Single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial extent of myocardial infarction compared with contrast-enhanced magnetic resonance

Author

I. Ak, P. Talavera, L. Freire, Alejandro Ricalde, H. W. Strauss, R. Campini, W. Burchert, A. Spanos, T. Terrance Chua, A. Andreyev, F. Tornes, Norihisa Tonami, G.P. Gian Piero Carboni, Y. Yang, Alejandro Solodky, M. Razzouk, Miguel Hernandez-Pampaloni, F. Keng, P. Giannuzzi, M. R. Kremer, F. Parthenakis, D. Boundas, A. Bischof-Delaloye, J. Valiente, I. Idy-Peretti, M. C. Amigo, Gautam Ramakrishna, M. C. Toufektsian, K. Schäfers, Tatsuo Kumazaki, G. Souretis, V. Prassopoulos, E. Eleuteri, F. G. Cosío, Claudio Marcassa, M. Redruello, V. Monda, K. T. Yang, A. van Aswegen, K. Åström, Maria Jose Martinez, A. Silvestri, J. Pereira, John O. Prior, D. Le Guludec, V. R. Dabagh Kakhki, M. Janier, S. Sumati Sundaraiya, E. Pulawski, Yoshihiro Yamada, Hiroaki Shimomura, C. P. Chen, K. Perisinakis, A. Amalia Peix, Turan Ege, A. Bossuyt, G. Bonzani, Henrik Hussein El-Ali, P. Arce, A. Olmsted, B. Cabale, S. Sumati, A. Oliveira, E. J. Garcia, E. Fricke, Kumita S, Deborah Tout, T. Lahoutte, Sybille Ziegler, J. B. Michel, P. Y. Marie, P. Perrone Filardi, Bilgin Timuralp, L. Nathan, Efstratios Moralidis, R. J. Gibbons, Emre Entok, D. Vilain, Y. H. Yi-Hwa Liu, A. Ali Sarikaya, E. Skrobowska, N. Karkavitsas, Michael Ljungberg, N. Teramoto, C. Lartizien, Christian Vanhove, Lars Edenbrandt, N. Perez Baliño, H. Pena, J. M. Vrigneaud, K. Seino, I. Guerrero, Taigo Kintaka, G. Storto, S. R. Underwood, F. Scapellato, W. Howe, Adel H. Allam, Todd D. Miller, B. Levkau, K. Matsumoto, S. Koukouraki, Andreas Kjaer, O. González, R. Miguel, Ian P. Clements, F. Rocha-Gonçalves, C. Weyman, F. Heres, P. Koslowski, G. Pekindil, K. Keiichi Cho, Thomas H. Schindler, D. Bendayan, M. A. Oxilia-Estigarribia, L. Lene Bindslev, P. Muto, J.P. Peter Wielepp, A. S. M. Abdel Fattah, F. Maskali, P. Strembelas, M. Schäfers, Muramori A, Arkadiusz Sitek, Yuksel Cavusoglu, Jonathan F. Tait, S. Maitrejean, Toshihiro Muramatsu, M. Michael Goris, B. W. Reutter, M. Catalano, Z. P. Ding, P. R. Franken, Christopher G.A. McGregor, Alexander I. Veress, T. Faria, Tsuyoshi Komori, Boris Zingerman, Gérald Vanzetto, Jürgen Schrader, G. Arsos, G. T. Grant Gullberg, F. Godinho, S. David, M. Mariana Vasconcelos, F. Macedo, K. Seki, H. Watabe, Brian P. Mullan, N. Karatzas, Lena Johansson, Erick Alexanderson, M. Eleta, A. Velidaki, H. Lieu, M. Slama, P. Gonçalves, N. Tran, A. Scalzone, A. Antoniou, Shimin Li, A. Papademetriou, S. Salihoglu, Aloha Meave, Frans J Th Wackers, S. Georga, M. Miglionico, T. Toufigh Gordi, M. L. Maria Luisa De Rimini, G. U. Guang-Uei Hung, V. V. Naidoo, L. Vidal, Alexander Sagie, Masoli O, K. W. Lee, A. Dongas, D. Baller, Yasuharu Ogura, Doumit Daou, J. Richter, A. Abdel Atty, I. Matsunari, T. Pellegrino, D. Daou, Mirosław Dziuk, K. B. Kirsten Bisgaard, Takahiro Higuchi, Catherine Ghezzi, H. Jabari, Isamu Narabayashi, Yasushi Kitaura, F. Rouzet, F. Kehren, T. Yamazaki, G. Martet, J. Misko, Jerome F. Breen, V. Torres, Masahiro Toba, Roxana Campisi, T. Nakajima, M. Tavolozza, Ka. Sambhasivam, Ronald H. Huesman, M. A. Balsa, J. Nloga, E. Martins, P. Calza, R. Weise, T. Suga, Peter Kies, O. Schober, M. H. S. Mandana Haack-Soerensen, K. M. Kim, Ulrich Flögel, L. Belardinelli, Birger Hesse, C. Y. Loong, A. Battah, Laure Sarda-Mantel, A. Veiga, Y. Yamamichi, H. R. Schelbert, C. Collaud, I. Monteforte, Philippe R. Franken, E. Vardareli, F. Ogresta, G. Brevetti, Alexis Broisat, S. Eckert, Itaru Adachi, A. R. Sorrentino, C. Coaguila, T. Zeniya, J. L. Vanderheyden, Lars Stegger, Penelope J. Thorley, L. K. Linda Kragh, F. Ponce, K. P. Schäfers, Fatma Aboul-Enein, Nili Zafrir, Shigeyuki Nishimura, R. Frank, A. Vargas, Steen Mortensen, D. Garcia-Barreto, Y. Shapira, C. Berthonneche, François Rouzet, P. Vardas, J. Koutsikos, Xiaoli Zhang, Seyed Rasoul Zakavi, Michael K. O'Connor, M. T. Alberca, Hongyun Zhu, Hidehiro Iida, T. H. Koh, R. Merenda, Atsuhiro Kawashima, Israel Mats, N. Natalia Maroz-Vadalajskaya, Junichi Taki, Albert J. Sinusas, Daniel Fagret, R. Lebtahi, Brian N. Bourke, Alberto Cuocolo, A. Patrianakos, Stephan G. Nekolla, K. Karakatsanis, C. Y. Lee, J. Qi, A. Warczynska, A. Fountos, Alvaro D. Facta, I Vassiliadis, V. Tsatkin, T. Wichter, Jens Kastrup, M. Defrise, A. Leenhardt, N. Pardal, P. Paula Awamleh, G. Guilhermina Cantinho, L. Riou, D. Horstkotte, C. Vanhove, J. Kawanami, Jeffrey A. Weiss, K. Kenichi Nakajima, P. L. Temporelli, H. Nakajo, O. Kardash, A. Benada, L. O. Cabrera, A. Meulemans, Milan Lomsky, and C. Komporozos

Subjects
medicine.medical_specialty, business.industry, medicine, Radiology, Nuclear Medicine and imaging, Medical physics, Instrumentation (computer programming), Cardiology and Cardiovascular Medicine, business
Published
2005
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14. Metoprolol in dilated cardiomyopathy

Author

Ian P. Clements and Wayne L. Miller

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Dilated cardiomyopathy, Cardiology and Cardiovascular Medicine, business, medicine.disease, Metoprolol, medicine.drug
Published
1997
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15. Effect of anterior ST depression on myocardial salvage assessed by technetium-99m sestamibi in patients with inferior myocardial infarction

Author

Raymond J. Gibbons, Ian P. Clements, Mark A. Evans, and Timothy F. Christian

Subjects
ST depression, medicine.medical_specialty, business.industry, Inferior Myocardial Infarction, Electrocardiography in myocardial infarction, Technetium-99m-sestamibi, Internal medicine, Cardiology, Medicine, Radiology, Nuclear Medicine and imaging, In patient, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Published
1995
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