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Your search keyword '"McDonald, Stuart J."' showing total 11 results
Start Over Author "McDonald, Stuart J." Journal journal of neurotrauma
11 results on '"McDonald, Stuart J."'

1. Clinical and Blood Biomarker Trajectories after Concussion: New Insights from a Longitudinal Pilot Study of Professional Flat-Track Jockeys

Author

McDonald, Stuart J., primary, Piantella, Stefan, additional, O'Brien, William T., additional, Hale, Matthew W., additional, O'Halloran, Paul, additional, Kinsella, Glynda, additional, Horan, Ben, additional, O'Brien, Terence J, additional, Maruff, Paul, additional, Shultz, Sandy R., additional, and Wright, Bradley J., additional

Published
2023
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2. Serum Protein Biomarkers of Inflammation, Oxidative Stress, and Cerebrovascular and Glial Injury in Concussed Australian Football Players

Author

Sun, Mujun, primary, Symons, Georgia F., additional, O'Brien, William T., additional, Mccullough, Jesse, additional, Aniceto, Roxanne, additional, Lin, I-Hsuan, additional, Eklund, Michael, additional, Brady, Rhys D., additional, Costello, Daniel, additional, Chen, Zhibin, additional, O'Brien, Terence J., additional, McDonald, Stuart J., additional, Agoston, Denes V., additional, and Shultz, Sandy R., additional

Published
2022
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4. Elevated Serum Interleukin-1β Levels in Male, but not Female, Collision Sport Athletes with a Concussion History

Author

O'Brien, William T., primary, Symons, Georgia F., additional, Bain, Jesse, additional, Major, Brendan P., additional, Costello, Daniel M., additional, Sun, Mujun, additional, Kimpton, Joshua S., additional, Chen, Zhibin, additional, Brady, Rhys D., additional, Mychasiuk, Richelle, additional, O'Brien, Terence J., additional, Monif, Mastura, additional, Shultz, Sandy R., additional, and McDonald, Stuart J., additional

Published
2021
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7. Mild Closed-Head Injury in Conscious Rats Causes Transient Neurobehavioral and Glial Disturbances: A Novel Experimental Model of Concussion

Author

Pham, Louise, primary, Shultz, Sandy R., additional, Kim, Hyun Ah, additional, Brady, Rhys D., additional, Wortman, Ryan C., additional, Genders, Shannyn G., additional, Hale, Matthew W., additional, O'Shea, Ross D., additional, Djouma, Elvan, additional, van den Buuse, Maarten, additional, Church, Jarrod E., additional, Christie, Brian R., additional, Drummond, Grant R., additional, Sobey, Christopher G., additional, and McDonald, Stuart J., additional

Published
2019
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8. Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

Author

Tan, Xin Lin, primary, Sun, Mujun, additional, Brady, Rhys D., additional, Liu, Shijie, additional, Llanos, Roxana, additional, Cheung, Steve, additional, Wright, David K., additional, Casillas-Espinosa, Pablo M., additional, Sashindranath, Maithili, additional, O'Brien, Terence J., additional, McDonald, Stuart J., additional, Turner, Bradley J., additional, and Shultz, Sandy R., additional

Published
2019
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9. Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion

Author

Clough, Meaghan, primary, Mutimer, Steven, additional, Wright, David K., additional, Tsang, Adrian, additional, Costello, Daniel M., additional, Gardner, Andrew J., additional, Stanwell, Peter, additional, Mychasiuk, Richelle, additional, Sun, Mujun, additional, Brady, Rhys D., additional, McDonald, Stuart J., additional, Webster, Kyria M., additional, Johnstone, Maddison R., additional, Semple, Bridgette D., additional, Agoston, Denes V., additional, White, Owen B., additional, Frayne, Richard, additional, Fielding, Joanne, additional, O'Brien, Terence J., additional, and Shultz, Sandy R., additional

Published
2018
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10. Experimental Traumatic Brain Injury Induces Bone Loss in Rats

Author

Brady, Rhys D., primary, Shultz, Sandy R., additional, Sun, Mujun, additional, Romano, Tania, additional, van der Poel, Chris, additional, Wright, David K., additional, Wark, John D., additional, O'Brien, Terence J., additional, Grills, Brian L., additional, and McDonald, Stuart J., additional

Published
2016
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11. Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury.

Author

Tan XL, Sun M, Brady RD, Liu S, Llanos R, Cheung S, Wright DK, Casillas-Espinosa PM, Sashindranath M, O'Brien TJ, McDonald SJ, Turner BJ, and Shultz SR

Abstract

Initial studies have found some evidence for transactive response DNA-binding protein 43 (TDP-43) abnormalities after traumatic brain injury (TBI), and the presence of protein inclusions consisting of TDP-43 are a pathological hallmark of amyotrophic lateral sclerosis (ALS), a condition associated with TBI. However, no study has characterized changes in TDP-43 phosphorylation, mislocalization, and fragmentation (i.e., abnormalities linked to hallmark TDP-43 pathology) after TBI, and how these relate to functional outcomes. Further, how TBI affects an individual with a known predisposition to TDP-43 pathology is unknown. Therefore, this study examined the effects of TBI on TDP-43 post-translational processing, localization, and behavioral outcomes in wild-type (WT) mice and mutant TDP-43 A315T mice (i.e., mice predisposed to TDP-43 pathology) at 24 h and 1 week after TBI. Post-mortem brain tissue from human patients with acute TBI was also examined. Western blots found that WT mice given TBI had increased TDP-43 phosphorylation, mislocalization, and fragmentation compared with sham-injured WT mice. The TDP-43 A315T mice given a TBI had exacerbated TDP-43 abnormalities, worse cell death, and cognitive deficits compared with all other groups. In the human TBI patients, the only significant finding was increased nuclear accumulation of phosphorylated TDP-43 fragments. The discrepancy between the robust mouse findings and the largely non-significant human findings may be due to factors including heterogeneity in clinical TBI, the small group sizes, and temporal complexities with TDP-43 abnormalities. These findings indicate that TBI can induce a number of TDP-43 abnormalities that may contribute to the neurological consequences of TBI, though further research is still needed.

Published
2018
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