1. Risk Factors and Characteristics of Intraoperative Seizures During Awake Craniotomy: A Retrospective Cohort Study of 562 Consecutive Patients With a Space-occupying Brain Lesion
- Author
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Hirokazu Takami, Tumul Chowdhury, Kok Weng Leong, Mark Bernstein, Abigail H. Daniels, Lashmi Venkatraghavan, Sudhakar Subramaniam, Gabriel Paquin-Lanthier, and Kawalpreet Singh
- Subjects
medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Medical record ,Retrospective cohort study ,Odds ratio ,Confidence interval ,Anesthesiology and Pain Medicine ,Anesthesia ,medicine ,Surgery ,Neurology (clinical) ,Neurosurgery ,Risk factor ,Dexmedetomidine ,business ,medicine.drug - Abstract
INTRODUCTION Intraoperative seizures (IOSs) during awake craniotomy (AC) are associated with significant morbidity. The reported incidence of IOS is between 3% and 30%. The aim of this study was to identify risk factors for IOS during AC for elective resection or biopsy of a space-occupying brain lesion. METHODS In this retrospective study, we reviewed the records of all awake craniotomies performed by a single neurosurgeon at a single university hospital between July 2006 and December 2018. IOS was defined as a clinically apparent seizure that occurred in the operating room and was documented in the medical records. Explanatory variables were chosen based on previously published literature on risk factors for IOS. RESULTS Five hundred and sixty-two patients had a total of 607 AC procedures during the study period; 581 cases with complete anesthesia records were included in analysis. Twenty-nine (5.0%) IOS events were reported during 29 (5%) awake craniotomies. Most seizures (27/29; 93%) were focal in nature and did not limit planned intraoperative stimulation mapping. Variables associated with IOS at a univariate P-value
- Published
- 2021