1. Increase of β-endorphin levels in cerebrospinal fluid but not in plasma in patients with cerebral infarction
- Author
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Tomoo Furui, Kyoko Satoh, Michiaki Hasuo, Yoshio Asano, Sadashi Shimosawa, and Tony L. Yaksh
- Subjects
Adult ,endocrine system ,medicine.medical_specialty ,Infarction ,(+)-Naloxone ,chemistry.chemical_compound ,Cerebrospinal fluid ,Internal medicine ,medicine ,Humans ,Endorphins ,Opioid peptide ,Aged ,Naloxone ,business.industry ,Cerebral infarction ,beta-Endorphin ,Therapeutic effect ,Cerebral Infarction ,Middle Aged ,medicine.disease ,Endocrinology ,chemistry ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
✓ β-Endorphin was measured in cerebrospinal fluid (CSF) and plasma in patients with cerebral infarction at acute (4 to 48 hours) and chronic (1 month) stages. Only CSF samples obtained in the acute stage showed β-endorphin values that were statistically higher than those measured in a control population. This finding suggests that infarction at its acute stage gives rise to an increased release of β-endorphin. Such a mechanism is consistent with the possibility that the reported therapeutic effect of naloxone in cerebral ischemic lesions may result in part from the antagonism of the centrally released endorphin, β-endorphin.
- Published
- 1984
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