1. Depletion of Perineuronal Nets Enhances Recognition Memory and Long-Term Depression in the Perirhinal Cortex.
- Author
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Romberg, Carola, Sujeong Yang, Melani, Riccardo, Andrews, Melissa R., Horner, Alexa E., Spillantini, Maria G., Bussey, Timothy J., Fawcett, James W., Pizzorusso, Tommaso, and Saksida, Lisa M.
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NEURONS ,RECOGNITION (Psychology) ,MEMORY ,MENTAL depression ,CEREBRAL cortex ,EXTRACELLULAR matrix ,PROTEIN structure - Abstract
Perineuronal nets (PNNs) are extracellular matrix structures surrounding cortical neuronal cell bodies and proximal dendrites and are involved in the control of brain plasticity and the closure of critical periods. Expression of the link protein Crtll/Haplnl in neurons has recently been identified as the key event triggering the formation of PNNs. Here we show that the genetic attenuation of PNNs in adult brain Crtl 1 knock-out mice enhances long-term object recognition memory and facilitates long-term depression in the perirhinal cortex, a neural correlate of object recognition memory. Identical prolongation of memory follows localized digestion of PNNs with chondroiti-nase ABC, an enzyme that degrades the chondroitin sulfate proteoglycan components of PNNs. The memory-enhancing effect of chon-droitinase ABC treatment attenuated over time, suggesting that the regeneration of PNNs gradually restored control plasticity levels. Our findings indicate that PNNs regulate both memory and experience-driven synaptic plasticity in adulthood. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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