1. Optogenetic Assessment of Horizontal Interactions in Primary Visual Cortex.
- Author
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Xiaoying Huang, Elyada, Yishai M., Bosking, William H., Walker, Theo, and Fitzpatrick, David
- Subjects
OPTOGENETICS ,VISUAL cortex ,TUPAIIDAE ,INTRINSIC optical imaging ,MAMMALS - Abstract
Columnar organization of orientation selectivity and clustered horizontal connections linking orientation columns are two of the dis-tinctive organizational features of primary visual cortex in many mammalian species. However, the functional role of these connections has been harder to characterize. Here we examine the extent and nature of horizontal interactions in VI of the tree shrew using optical imaging of intrinsic signals, optogenetic stimulation, and multi-unit recording. Surprisingly, we find the effects of optogenetic stimula-tion depend primarily on distance and not on the specific orientation domains or axes in the cortex, which are stimulated. In addition, across a wide range of variation in both visual and optogenetic stimulation we find linear addition of the two inputs. These results emphasize that the cortex provides a rich substrate for functional interactions that are not limited to the orientation-specific interactions predicted by the monosynaptic distribution of horizontal connections. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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