1. Transgenerational Transmission of Hyperactivity in a Mouse Model of ADHD.
- Author
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Zhu, Jinmin, Lee, Kevin P., Spencer, Thomas J., Biederman, Joseph, and Bhide, Pradeep G.
- Subjects
LABORATORY mice ,ATTENTION-deficit hyperactivity disorder ,NICOTINE addiction ,HUMAN phenotype ,BRAIN abnormalities ,ETIOLOGY of diseases ,GENETICS - Abstract
Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral disorder affecting children and adults. Genetic and environmental factors are associated with the etiology of ADHD. Among the environmental factors, exposure of the developing brain to nicotine is considered a major risk factor. Recent evidence suggests that environmental influences on the brain and behavior may be transmitted from one generation to the next. We used a prenatal nicotine exposure (PNE) mouse model of ADHD to test the hypothesis that PNEinduced hyperactivity, a proxy for human ADHD phenotype, is transmitted from one generation to the next. Our data reveal transgenerational transmission of PNE-induced hyperactivity in mice via the maternal but not the paternal line of descent. We suggest that transgenerational transmission is a plausible mechanism for propagation of environmentally induced ADHD phenotypes in the population. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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