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Several electrophysiological studies suggest that Parkinson's disease (PD) patients have a reduced tendency to entrain to regular environmental patterns. Here we investigate whether this reduced entrainment concerns a generalized deficit or is confined to movement-related activity, leaving sensory entrainment intact. Magnetoencephalography was recorded during a rhythmic auditory target detection task in 14 PD patients and 14 control subjects. Participants were instructed to press a button when hearing a target tone amid an isochronous sequence of standard tones. The variable pitch of standard tones indicated the probability of the next tone to be a target. In addition, targets were occasionally omitted to evaluate entrainment uncontaminated by stimulus effects. Response times were not significantly different between groups and both groups benefited equally from the predictive value of standard tones. Analyses of oscillatory beta power over auditory cortices showed equal entrainment to the tones in both groups. By contrast, oscillatory beta power and event-related fields demonstrated a reduced engagement of motor cortical areas in PD patients, expressed in the modulation depth of beta power, in the response to omitted stimuli, and in an absent motor area P300 effect. Together, these results show equally strong entrainment of neural activity over sensory areas in controls and patients, but, in patients, a deficient translation of the adjustment to the task rhythm to motor circuits. We suggest that the reduced activation reflects not merely altered resonance to rhythmic external events, but a compromised recruitment of an endogenous response reflecting internal rhythm generation. NEW & NOTEWORTHY: Previous studies suggest that motor cortical activity in PD patients has a reduced tendency to entrain to regular environmental patterns. This study demonstrates that the deficient entrainment in PD concerns the motor system only, by showing equally strong entrainment of neural activity over sensory areas in controls and patients but, in patients, a deficient translation of this adjustment to the task rhythm to motor circuits. [ABSTRACT FROM AUTHOR]

Choice behavior is influenced by factors such as reward and number of alternatives but also by physical context, for instance, the relative position of alternative movement targets. At small separation, speeded eye or hand movements are more likely to land between targets (spatial averaging) than at larger separation. Neurocomputational models explain such behavior in terms of cortical activity being preshaped by the movement environment. Here, we manipulate target separation, as a determinant of motor cortical activity in choice behavior, to address neural mechanisms of response selection. Specifically, we investigate whether context-induced changes in the balance of cooperative and competitive interactions between competing groups of neurons are expressed in the power spectrum of sensorimotor rhythms. We recorded magnetoencephalography while participants were precued to two possible movement target locations at different angles of separation (30, 60, or 90°). After a delay, one of the locations was cued as the target for a joystick pointing movement. We found that late delay-period movement-preparatory activity increased more strongly for alternative targets at 30 than at 60 or 90° of separation. This nonlinear pattern was evident in slow event-related fields as well as in beta- and low-gamma-band suppression. A comparable pattern was found within an earlier window for theta-band synchronization. We interpret the late delay effects in terms of increased movement-preparatory activity when there is greater overlap and hence less competition between groups of neurons encoding two response alternatives. Early delayperiod theta-band synchronization may reflect covert response activation relevant to behavioral spatial averaging effects. [ABSTRACT FROM AUTHOR]

The objective of this study was to systematically characterize motor units (MUs) of the musculature of the lower face. MU endplate positions and principal muscle fiber orientations relative to facial landmarks were identified. This was done by the analysis of motor unit action potentials (MUAPs) in the surface electromyogram. Thirteen specially trained, healthy subjects performed selective contractions of the depressor anguli oris, depressor labii inferioris, mentalis, and orbicularis oris inferior muscles. Signals were recorded using recently developed, 0.3-mm thin and flexible high-density surface electromyography (sEMG) grids (120 channels). For each subject and each muscle and for different low contraction levels, representative MUAPs (“MU fingerprints”) were extracted from the raw sEMG data according to their spatiotemporal amplitude characteristics. We then topographically characterized the lower facial MUs’ endplate zones and main muscle fiber orientations on the individual faces of the subjects. These topographical MU parameters were spatially warped to correct for the different sizes and shapes of the faces of individual subjects. This electrophysiological study revealed a distribution of the lower facial MU endplates in more or less restricted, distinct clusters on the muscle often with eccentric locations. The results add substantially to the basic neurophysiologic and anatomical knowledge of the complex facial muscle system. They can also be used to establish objective guidelines for placement of conventional (surface or needle) EMG electrodes as well as for clinical investigations on neuromuscular diseases affecting the facial musculature. The localized endplate positions may also indicate optimal locations for botulinum toxin injection in the face. [ABSTRACT FROM AUTHOR]