1. Malignant Melanoma Metastatic to Oligodendroglioma: Case Report and Literature Review of Tumor-to-Tumor Metastasis to Gliomas.
- Author
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Giantini Larsen A, Grannan BL, Lee CK, Koch MJ, Williams EA, Frosch MP, and Cahill DP
- Subjects
- Aged, Brain Neoplasms diagnostic imaging, Brain Neoplasms surgery, Cognition Disorders psychology, Disease Progression, Fatal Outcome, Glioma diagnostic imaging, Glioma surgery, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Male, Melanoma diagnostic imaging, Melanoma surgery, Neoplasm Metastasis, Neurosurgical Procedures, Oligodendroglioma diagnostic imaging, Oligodendroglioma surgery, Brain Neoplasms pathology, Glioma pathology, Melanoma pathology, Oligodendroglioma pathology
- Abstract
Tumor-to-tumor metastasis is an uncommon phenomenon, and a metastasis from an extracranial donor tumor to an intracranial recipient tumor is extremely rare. In particular, there are only 14 cases reported in the literature that describe a tumor-to-tumor metastasis involving a glioma. We present a rare case of an 83-year-old man with an 11-year history of lentigo maligna melanoma who presented with impaired balance and cognitive slowing and was found to have rapid progression of a previously known indolent right frontal brain mass. Pathologic examination of the tumor after resection revealed the presence of both malignant melanoma and an oligodendroglioma WHO grade II. To the best of our knowledge, this is the first reported case of malignant melanoma metastasizing to an oligodendroglioma that has been confirmed by immunohistochemistry and genetic analysis.
- Published
- 2018
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