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Your search keyword '"P. Canu"' showing total 19 results
Start Over Author "P. Canu" Journal journal of neurology
19 results on '"P. Canu"'

1. How to detect affect recognition alterations in amyotrophic lateral sclerosis

Author

Castelnovo, Veronica, Canu, Elisa, Aiello, Edoardo Nicolò, Curti, Beatrice, Sibilla, Elisa, Torre, Silvia, Freri, Fabiola, Tripodi, Chiara, Lumaca, Laura, Spinelli, Edoardo Gioele, Schito, Paride, Russo, Tommaso, Falzone, Yuri, Verde, Federico, Silani, Vincenzo, Ticozzi, Nicola, Sturm, Virginia E., Rankin, Katherine P., Gorno-Tempini, Maria Luisa, Poletti, Barbara, Filippi, Massimo, and Agosta, Federica

Published
2024
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2. Clinical and neuroanatomical characterization of the semantic behavioral variant of frontotemporal dementia in a multicenter Italian cohort

Author

Ghirelli, Alma, Spinelli, Edoardo Gioele, Canu, Elisa, Basaia, Silvia, Castelnovo, Veronica, Cecchetti, Giordano, Sibilla, Elisa, Domi, Teuta, Magnani, Giuseppe, Caso, Francesca, Caroppo, Paola, Prioni, Sara, Villa, Cristina, Rossi, Giacomina, Tremolizzo, Lucio, Appollonio, Ildebrando, Verde, Federico, Ticozzi, Nicola, Silani, Vincenzo, Filippi, Massimo, and Agosta, Federica

Published
2024
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5. Case report: coexistence of C9orf72 expansion and progranulin mutation in a case of genetic frontotemporal dementia—clinical features and neuroimaging correlates

Author

Ghirelli, Alma, Spinelli, Edoardo Gioele, Canu, Elisa, Domi, Teuta, Basaia, Silvia, Castelnovo, Veronica, Pozzi, Laura, Magnani, Giuseppe, Caso, Francesca, Caroppo, Paola, Prioni, Sara, Villa, Cristina, Riva, Nilo, Quattrini, Angelo, Carrera, Paola, Filippi, Massimo, and Agosta, Federica

Published
2023
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9. Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study

Author

Cecchetti, Giordano, Agosta, Federica, Canu, Elisa, Basaia, Silvia, Barbieri, Alessandra, Cardamone, Rosalinda, Bernasconi, Maria Paola, Castelnovo, Veronica, Cividini, Camilla, Cursi, Marco, Vabanesi, Marco, Impellizzeri, Matteo, Lazzarin, Serena Marita, Fanelli, Giovanna Franca, Minicucci, Fabio, Giacalone, Giacomo, Falini, Andrea, Falautano, Monica, Rovere-Querini, Patrizia, Roveri, Luisa, and Filippi, Massimo

Published
2022
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16. A multimodal neuroimaging study of a case of crossed nonfluent/agrammatic primary progressive aphasia

Author

Spinelli, Edoardo G, Caso, Francesca, Agosta, Federica, Gambina, Giuseppe, Magnani, Giuseppe, Canu, Elisa, Blasi, Valeria, Perani, Daniela, Comi, Giancarlo, Falini, Andrea, Gorno-Tempini, Maria Luisa, and Filippi, Massimo

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Rehabilitation, Biomedical Imaging, Cerebrovascular, Aging, Brain Disorders, Stroke, Minority Health, Aphasia, Acquired Cognitive Impairment, Clinical Research, Rare Diseases, Neurodegenerative, Neurological, Aphasia, Broca, Disease Progression, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Multimodal Imaging, Positron-Emission Tomography, Primary Progressive Nonfluent Aphasia, Crossed aphasia, Nonfluent/agrammatic primary progressive aphasia, Functional MRI, 18-Fluorodeoxyglucose positron emission tomography, Diffusion tensor tractography, Corticobasal syndrome, Neurology & Neurosurgery, Clinical sciences
Abstract

Crossed aphasia has been reported mainly as post-stroke aphasia resulting from brain damage ipsilateral to the dominant right hand. Here, we described a case of a crossed nonfluent/agrammatic primary progressive aphasia (nfvPPA), who developed a corticobasal syndrome (CBS). We collected clinical, cognitive, and neuroimaging data for four consecutive years from a 55-year-old right-handed lady (JV) presenting with speech disturbances. 18-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) and DaT-scan with (123)I-Ioflupane were obtained. Functional MRI (fMRI) during a verb naming task was acquired to characterize patterns of language lateralization. Diffusion tensor MRI was used to evaluate white matter damage within the language network. At onset, JV presented with prominent speech output impairment and right frontal atrophy. After 3 years, language deficits worsened, with the occurrence of a mild agrammatism. The patient also developed a left-sided mild extrapyramidal bradykinetic-rigid syndrome. The clinical picture was suggestive of nfvPPA with mild left-sided extrapyramidal syndrome. At this time, voxel-wise SPM analyses of (18)F-FDG PET and structural MRI showed right greater than left frontal hypometabolism and damage, which included the Broca's area. DaT-scan showed a reduced uptake in the right striatum. FMRI during naming task demonstrated bilateral language activations, and tractography showed right superior longitudinal fasciculus (SLF) involvement. Over the following year, JV became mute and developed frank left-sided motor signs and symptoms, evolving into a CBS clinical picture. Brain atrophy worsened in frontal areas bilaterally, and extended to temporo-parietal regions, still with a right-sided asymmetry. Tractography showed an extension of damage to the left SLF and right inferior longitudinal fasciculus. We report a case of crossed nfvPPA followed longitudinally and studied with advanced neuroimaging techniques. The results highlight a complex interaction between individual premorbid developmental differences and the clinical phenotype.

Published
2015

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