1. Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study
- Author
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Alex Buoite Stella, Miloš Ajčević, Paolo Manganotti, Giovanni Furlanis, Nicolò Arjuna Frezza, Romina Valentinotti, Buoite Stella, Alex, Furlanis, Giovanni, Frezza, Nicolò Arjuna, Valentinotti, Romina, Ajcevic, Milo, and Manganotti, Paolo
- Subjects
Male ,COMPASS-31 ,medicine.medical_specialty ,Neurology ,Autonomic dysfunction ,Orthostatic intolerance ,Hypotension, Orthostatic ,Orthostatic vital signs ,Internal medicine ,Heart rate ,medicine ,Humans ,long-COVID ,Prospective Studies ,COVID-19 ,Original Communication ,SARS-CoV-2 ,business.industry ,Dysautonomia ,medicine.disease ,Blood pressure ,Autonomic Nervous System Diseases ,Ambulatory ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Complication - Abstract
The autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may be a possible complication in post-COVID individuals. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been suggested to be common after SARS-CoV-2 infection, but other components of ANS function may be also impaired. The Composite Autonomic Symptom Scale 31 (COMPASS-31) questionnaire is a simple and validated tool to assess dysautonomic symptoms. The aim of the present study was to administer the COMPASS-31 questionnaire to a sample of post-COVID patients with and without neurological complaints. Participants were recruited among the post-COVID ambulatory services for follow-up evaluation between 4 weeks and 9 months from COVID-19 symptoms onset. Participants were asked to complete the COMPASS-31 questionnaire referring to the period after COVID-19 disease. Heart rate and blood pressure were manually taken during an active stand test for OH and POTS diagnosis. One-hundred and eighty participants were included in the analysis (70.6% females, 51 ± 13 years), and OH was found in 13.8% of the subjects. Median COMPASS-31 score was 17.6 (6.9–31.4), with the most affected domains being orthostatic intolerance, sudomotor, gastrointestinal and pupillomotor dysfunction. A higher COMPASS-31 score was found in those with neurological symptoms (p p p p p
- Published
- 2021