1. REM sleep behavior disorder in Japanese patients with Parkinson’s disease: a multicenter study using the REM sleep behavior disorder screening questionnaire
- Author
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Kazuhiro Muramatsu, Kouichi Ohta, Kazuo Isozumi, Yoshihiro Nihei, Morinobu Seki, Atsuo Koto, Satoko Iwasawa, Jun Gotoh, Hideki Sato, Yutaka Tomita, Keiji Yamaguchi, Kazushi Takahashi, Ban Mihara, Norihiro Suzuki, and Yoko Morita
- Subjects
Adult ,Male ,medicine.medical_specialty ,Parkinson's disease ,Neurology ,Population ,REM Sleep Behavior Disorder ,Disease ,REM sleep behavior disorder ,Asian People ,Rating scale ,Surveys and Questionnaires ,Internal medicine ,medicine ,Humans ,Mass Screening ,education ,Aged ,Neuroradiology ,Aged, 80 and over ,education.field_of_study ,Parkinson Disease ,Middle Aged ,medicine.disease ,REM Sleep Behavior Disorder Screening Questionnaire ,Physical therapy ,Female ,Neurology (clinical) ,Psychology - Abstract
REM sleep behavior disorder (RBD) is known to be observed more frequently in patients with an α-synucleinopathy such as Parkinson’s disease (PD) than in the general population. The precise prevalence of RBD in Japanese PD patients is not known. Therefore, we investigated the prevalence and the clinical characteristics of patients with RBD in a large population of Japanese patients with PD. We investigated various clinical features and employed the Japanese version of the RBD screening questionnaire on 469 non-demented Japanese PD patients in this multicenter study. Probable or possible RBD was detected in 146 patients (31.1%) and was significantly associated with longer PD duration, higher Hoehn and Yahr stage, higher Unified Parkinson’s Disease Rating Scale part III subscale (7 items), more motor fluctuations, and a higher levodopa-equivalent daily dose (p
- Published
- 2012
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