1. Superficial siderosis is a warning sign for future intracranial hemorrhage.
- Author
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Linn, Jennifer, Wollenweber, Frank, Lummel, Nina, Bochmann, Katja, Pfefferkorn, Thomas, Gschwendtner, Andreas, Bruckmann, Hartmut, Dichgans, Martin, and Opherk, Christian
- Subjects
BRAIN diseases ,CEREBRAL amyloid angiopathy ,SUBARACHNOID hemorrhage ,CEREBRAL hemorrhage ,MAGNETIC resonance imaging of the brain ,MEDICAL statistics - Abstract
Supratentorial superficial siderosis (SS) is a frequent imaging marker of cerebral amyloid angiopathy (CAA). It is most probably caused by focal subarachnoid hemorrhages (fSAHs). Based on single-case observations, it has been proposed that such fSAHs might be a predisposing factor for future intracranial hemorrhage. Here we tested the hypothesis if a SS as a residue of fSAHs must be regarded as a warning sign for future intracranial hemorrhage. Fifty-one consecutive patients with SS and no apparent cause other than possible or probable CAA were identified through a database search and followed-up for a median interval of 35.3 months (range 6-120 months). Main outcome measures were rate and location of new intracranial hemorrhages. Twenty-four patients (47.1 %) had experienced any new intracranial hemorrhage, 18 patients (35.3 %) had an intracerebral hemorrhage (ICH), and in 13 of them (25.5 %), the hemorrhage was located at the site of pre-existing siderosis. Six patients (11.7 %) had developed a new subarachnoid hemorrhage (SAH), four of them at the site of siderosis. Patients with SS are at substantial risk for subsequent intracranial hemorrhage. SS can be considered a warning sign of future ICH or SAH, which frequently occur adjacent to pre-existing SS. Prospective studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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