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Start Over Author "Nicholson, Timothy" Journal journal of neurology, neurosurgery & psychiatry
30 results on '"Nicholson, Timothy"'

1. Unravelling the influence of affective stimulation on functional neurological symptoms: a pilot experiment examining potential mechanisms.

Author

Pick, Susannah, Millman, L. S. Merritt, Ward, Emily, Short, Eleanor, Stanton, Biba, Reinders, A. A. T. Simone, Winston, Joel S., Nicholson, Timothy R., Edwards, Mark J., Goldstein, Laura H., David, Anthony S., Chalder, Trudie, Hotopf, Matthew, and Mehta, Mitul A.

Subjects
INTEROCEPTION, PSYCHOGENIC nonepileptic seizures, EPILEPSY, PILOT projects, AFFECT (Psychology), SOMATOFORM disorders, PATIENTS' attitudes, YOUNG adults
Published
2024
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2. 13 Predisposing, precipitating and perpetuating factors in functional neurological disorder: a pilot study

Author

Merritt Millman, LS, primary, Short, Eleanor, additional, Ward, Emily, additional, Sun, Yiqing, additional, Stanton, Biba, additional, Bradley-Westguard, Abigail, additional, Goldstein, Laura H, additional, Winston, Joel, additional, Mehta, Mitul, additional, Nicholson, Timothy, additional, Reinders, Simone, additional, David, Anthony, additional, Edwards, Mark, additional, Chalder, Trudie, additional, Hotopf, Matthew, additional, and Pick, Susannah, additional

Published
2023
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3. 12 A pilot investigation of interoceptive accuracy, awareness, and sensibility in functional neurological disorder

Author

Merritt Millman, LS, primary, Short, Eleanor, additional, Stanton, Biba, additional, Winston, Joel, additional, Nicholson, Timothy, additional, Mehta, Mitul, additional, Reinders, Simone, additional, Edwards, Mark, additional, Goldstein, Laura, additional, David, Anthony, additional, Hotopf, Matthew, additional, Chalder, Trudie, additional, and Pick, Susannah, additional

Published
2023
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4. Unravelling the influence of affective stimulation on functional neurological symptoms: a pilot experiment examining potential mechanisms

Author

Pick, Susannah, primary, Millman, LS Merritt, additional, Ward, Emily, additional, Short, Eleanor, additional, Stanton, Biba, additional, Reinders, AAT Simone, additional, Winston, Joel S, additional, Nicholson, Timothy R, additional, Edwards, Mark J, additional, Goldstein, Laura H, additional, David, Anthony S, additional, Chalder, Trudie, additional, Hotopf, Matthew, additional, and Mehta, Mitul A, additional

Published
2023
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7. Considerations for causality assessment of neurological and neuropsychiatric complications of SARS-CoV-2 vaccines: from cerebral venous sinus thrombosis to functional neurological disorder

Author

Butler, Matt, primary, Tamborska, Arina, additional, Wood, Greta K, additional, Ellul, Mark, additional, Thomas, Rhys H, additional, Galea, Ian, additional, Pett, Sarah, additional, Singh, Bhagteshwar, additional, Solomon, Tom, additional, Pollak, Thomas Arthur, additional, Michael, Benedict D, additional, and Nicholson, Timothy R, additional

Published
2021
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8. Neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives

Author

Rogers, Jonathan P, primary, Watson, Cameron J, additional, Badenoch, James, additional, Cross, Benjamin, additional, Butler, Matthew, additional, Song, Jia, additional, Hafeez, Danish, additional, Morrin, Hamilton, additional, Rengasamy, Emma Rachel, additional, Thomas, Lucretia, additional, Ralovska, Silviya, additional, Smakowski, Abigail, additional, Sundaram, Ritika Dilip, additional, Hunt, Camille Kaitlyn, additional, Lim, Mao Fong, additional, Aniwattanapong, Daruj, additional, Singh, Vanshika, additional, Hussain, Zain, additional, Chakraborty, Stuti, additional, Burchill, Ella, additional, Jansen, Katrin, additional, Holling, Heinz, additional, Walton, Dean, additional, Pollak, Thomas A, additional, Ellul, Mark, additional, Koychev, Ivan, additional, Solomon, Tom, additional, Michael, Benedict Daniel, additional, Nicholson, Timothy R, additional, and Rooney, Alasdair G, additional

Published
2021
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17. 8 Catatonia: demographic, clinical and laboratory associations in a large dataset

Author

Rogers, Jonathan P, primary, Pollak, Thomas A, additional, Begum, Nazifa, additional, Griffin, Anna, additional, Carter, Ben, additional, Pritchard, Megan, additional, Broadbent, Matthew, additional, Kolliakou, Anna, additional, Stewart, Robert, additional, Patel, Rashmi, additional, Bomford, Adrian, additional, Amad, Ali, additional, Nicholson, Timothy, additional, and David, Anthony S, additional

Published
2020
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21. Defining causality in COVID-19 and neurological disorders

Author

Ellul, Mark, primary, Varatharaj, Aravinthan, additional, Nicholson, Timothy R, additional, Pollak, Thomas Arthur, additional, Thomas, Naomi, additional, Easton, Ava, additional, Zandi, Michael S, additional, Manji, Hadi, additional, Solomon, Tom, additional, Carson, Alan, additional, Turner, Martin R, additional, Kneen, Rachel, additional, Galea, Ian, additional, Pett, Sarah, additional, Thomas, Rhys Huw, additional, and Michael, Benedict Daniel, additional

Published
2020
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22. Outcome measurement in functional neurological disorder: a systematic review and recommendations

Author

Pick, Susannah, primary, Anderson, David G, additional, Asadi-Pooya, Ali A, additional, Aybek, Selma, additional, Baslet, Gaston, additional, Bloem, Bastiaan R, additional, Bradley-Westguard, Abigail, additional, Brown, Richard J, additional, Carson, Alan J, additional, Chalder, Trudie, additional, Damianova, Maria, additional, David, Anthony S, additional, Edwards, Mark J, additional, Epstein, Steven A, additional, Espay, Alberto J, additional, Garcin, Béatrice, additional, Goldstein, Laura H, additional, Hallett, Mark, additional, Jankovic, Joseph, additional, Joyce, Eileen M, additional, Kanaan, Richard A, additional, Keynejad, Roxanne C, additional, Kozlowska, Kasia, additional, LaFaver, Kathrin, additional, LaFrance, Jr., W Curt, additional, Lang, Anthony E, additional, Lehn, Alex, additional, Lidstone, Sarah, additional, Maurer, Carine W, additional, Mildon, Bridget, additional, Morgante, Francesca, additional, Myers, Lorna, additional, Nicholson, Clare, additional, Nielsen, Glenn, additional, Perez, David L, additional, Popkirov, Stoyan, additional, Reuber, Markus, additional, Rommelfanger, Karen S, additional, Schwingenshuh, Petra, additional, Serranova, Tereza, additional, Shotbolt, Paul, additional, Stebbins, Glenn T, additional, Stone, Jon, additional, Tijssen, Marina AJ, additional, Tinazzi, Michele, additional, and Nicholson, Timothy R, additional

Published
2020
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25. Stress and functional neurological disorders: mechanistic insights.

Author

Keynejad, Roxanne C., Frodl, Thomas, Kanaan, Richard, Pariante, Carmine, Reuber, Markus, and Nicholson, Timothy R.

Subjects
NEUROLOGICAL disorders, ACUTE stress disorder, PHOBIAS, LIFE change events
Abstract

At the interface between mind and body, psychiatry and neurology, functional neurological disorder (FND) remains poorly understood. Formerly dominant stress-related aetiological models have been increasingly challenged, in part due to cases without any history of past or recent trauma. In this perspective article, we review current evidence for such models, and how research into the role of traumatic stress in other disorders and the neurobiology of the stress response can inform our mechanistic understanding of FND. First, we discuss the association between stress and the onset or exacerbation of a variety of physical and mental health problems. Second, we review the role of hypothalamic-pituitary-adrenal axis dysfunction in the neurobiology of ill-health, alongside evidence for similar mechanisms in FND. Third, we advocate a stress-diathesis model, in which biological susceptibility interacts with early life adversity, where FND can be precipitated by traumatic events later in life and maintained by psychological responses. We hypothesise that greater biological susceptibility to FND is associated with less severe remote and recent stress, and that FND precipitated by more severe stress is associated with lower biological vulnerability. This would explain clinical experience of variable exposure to historical and recent traumatic stress among people with FND and requires empirical investigation. A testable, evidence-based stress-diathesis model can inform nuanced understanding of how biological and psychological factors interact at the individual level, with potential to inform personalised treatment pathways. Much-needed research to establish the aetiology of FND will enhance clinical care and communication, facilitate effective treatment and inform prevention strategies. [ABSTRACT FROM AUTHOR]

Published
2019
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26. Emotional processing in functional neurological disorder: a review, biopsychosocial model and research agenda.

Author

Pick, Susannah, Goldstein, Laura H., Perez, David L., and Nicholson, Timothy R.

Subjects
NEUROLOGICAL disorders, BIOPSYCHOSOCIAL model, INTEROCEPTION, PSYCHOGENIC nonepileptic seizures, FACIAL expression & emotions (Psychology)
Abstract

Functional neurological disorder (FND) is a common and highly disabling disorder, but its aetiology remains enigmatic. Conceptually, there has been reduced emphasis on the role of psychosocial stressors in recent years, with a corresponding increase in neurobiological explanations. However, a wealth of evidence supports the role of psychosocial adversities (eg, stressful life events, interpersonal difficulties) as important risk factors for FND. Therefore, there is a need to integrate psychosocial (environmental) and neurobiological factors (eg, sensorimotor and cognitive functions) in contemporary models of FND. Altered emotional processing may represent a key link between psychosocial risk factors and core features of FND. Here, we summarise and critically appraise experimental studies of emotional processing in FND using behavioural, psychophysiological and/or neuroimaging measures in conjunction with affective processing tasks. We propose that enhanced preconscious (implicit) processing of emotionally salient stimuli, associated with elevated limbic reactivity (eg, amygdala), may contribute to the initiation of basic affective/defensive responses via hypothalamic and brainstem pathways (eg, periaqueductal grey). In parallel, affect-related brain areas may simultaneously exert a disruptive influence on neurocircuits involved in voluntary motor control, awareness and emotional regulation (eg, sensorimotor, salience, central executive networks). Limbic-paralimbic disturbances in patients with FND may represent one of several neurobiological adaptations linked to early, severe and/or prolonged psychosocial adversity. This perspective integrates neurobiological and psychosocial factors in FND and proposes a research agenda, highlighting the need for replication of existing findings, multimodal sampling across emotional response domains and further examination of emotional influences on sensorimotor and cognitive functions in FND populations. [ABSTRACT FROM AUTHOR]

Published
2019
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30. Defining causality in COVID-19 and neurological disorders.

Author

Ellu, Mark, Varatharaj, Aravinthan, Nicholson, Timothy R., Pollak, Thomas Arthur, Thomas, Naomi, Easton, Ava, Zandi, Michael S., Manji, Hadi, Solomon, Tom, Carson, Alan, Turner, Martin R., Kneen, Rachel, Galea, Ian, Pett, Sarah, Thomas, Rhys Huw, Michael, Benedict Daniel, Ellul, Mark, and CoroNerve Steering Committee

Subjects
NEUROLOGICAL disorders, COVID-19, NEUROLOGIC manifestations of general diseases, SARS-CoV-2, ETIOLOGY of diseases
Published
2020
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