1. Localised 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV
- Author
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P. Giannini, Isabella Laura Simone, D. Carrara, A. Bellacosa, G. B. Zimatore, F. Federico, Carla Tortorella, Paolo Livrea, P Picciola, Gioacchino Angarano, C.F. Andreula, and V. Lucivero
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,AIDS Dementia Complex ,Magnetic Resonance Spectroscopy ,Adolescent ,Lymphoma ,HIV Infections ,Sensitivity and Specificity ,Choline ,Diagnosis, Differential ,Central nervous system disease ,Leukoencephalopathy ,Immunopathology ,Centrum semiovale ,medicine ,Humans ,Aspartic Acid ,business.industry ,Leukoencephalopathy, Progressive Multifocal ,virus diseases ,Middle Aged ,Creatine ,medicine.disease ,Toxoplasmosis ,Hyperintensity ,Psychiatry and Mental health ,nervous system ,Case-Control Studies ,Toxoplasmosis, Cerebral ,Papers ,Female ,Surgery ,Neurology (clinical) ,Differential diagnosis ,business - Abstract
OBJECTIVES—To evaluate the role of proton MR spectroscopy (1H-MRS) in detecting metabolic changes in diffuse or focal lesions in the brain of patients infected with HIV. METHODS—Sixty HIV seropositive patients (25 with HIV related encephalopathies, 20 with toxoplasmosis, eight with progressive multifocal leukoencephalopathies (PMLs), and seven with lymphomas) and 22HIV seronegative neurological controls were examined with a combined MRI and1H-MRS technique using a Siemens 1.5 Tesla Magnetom. Spectra (Spin Echo sequence, TE 135 ms) were acquired by single voxel, localised on focal lesions in toxoplasmosis, PML, lymphomas, and HIV encephalopathies and on the centrum semiovale of neurological controls. Choline (Cho), creatine (Cr), N-acetyl aspartate (NAA), lactate, and lipids were evaluated in each spectrum and NAA/Cr, NAA/Cho, and Cho/Cr ratios were calculated. RESULTS—A significant decrease in NAA/Cr and NAA/Cho ratios were found in all HIV diagnostic groups in comparison with neurological controls (p
- Published
- 1998
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