1. Relationship between white matter integrity and post-traumatic cognitive deficits: a systematic review and meta-analysis
- Author
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Ruili Wei, Ruidong Cheng, Fangping He, Benyan Luo, Jie Zhang, Liang Tian, Juebao Li, Li Zhang, and Xiangming Ye
- Subjects
Fornix, Brain ,Gyrus Cinguli ,Corpus Callosum ,White matter ,03 medical and health sciences ,Executive Function ,0302 clinical medicine ,Internal Capsule ,Memory ,Fractional anisotropy ,Brain Injuries, Traumatic ,medicine ,Cingulum (brain) ,Humans ,Attention ,Cognitive Dysfunction ,Cognitive decline ,Neuropsychology ,Cognition ,Executive functions ,White Matter ,Psychiatry and Mental health ,medicine.anatomical_structure ,Diffusion Tensor Imaging ,Anisotropy ,Surgery ,Neurology (clinical) ,Psychology ,030217 neurology & neurosurgery ,Diffusion MRI ,Clinical psychology - Abstract
ObjectiveTo investigate relationships between cognitive domains and white matter changes in different regions in patients with cognitive deficits after traumatic brain injury (TBI).MethodsDatabases including PubMed, Embase, Web of Science and CENTRAL were searched for studies published before 5 August 2017. Correlation coefficients between cognition and white matter integrity, measured by diffusion metrics, including fractional anisotropy (FA), were pooled from 49 studies including 1405 patients. The influence of demographic factors was assessed by meta-regression analysis.ResultsSignificant pooled FA–executive correlations (pConclusionsFA is the most sensitive metric for detecting post-TBI cognitive decline across various domains. Representative white matter regions, such as the CC and IC, perform better than whole-brain white matter for reflecting a wide range of cognitive domains, including memory, attention and executive functions. Moreover, the fornix and cingulum particularly reflect memory function. They yield insights into particular imaging indicators that have neuropsychological value.
- Published
- 2017