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Start Over Author "Ventura E." Journal journal of neuroimmunology
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5. T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6 x SJL) F1 mice.

Author

Zhang GX, Yu S, Gran B, Li J, Calida D, Ventura E, Chen X, and Rostami A

Subjects
Analysis of Variance, Animals, Cells, Cultured, Cytokines metabolism, Encephalomyelitis, Autoimmune, Experimental etiology, Encephalomyelitis, Autoimmune, Experimental pathology, Enzyme-Linked Immunosorbent Assay methods, Flow Cytometry methods, Glycoproteins immunology, Histological Techniques, Immunization methods, Immunoglobulin G blood, Lymphocyte Activation, Mice, Mice, Inbred Strains, Multiple Sclerosis, Chronic Progressive etiology, Multiple Sclerosis, Chronic Progressive immunology, Multiple Sclerosis, Chronic Progressive pathology, Multiple Sclerosis, Relapsing-Remitting etiology, Multiple Sclerosis, Relapsing-Remitting pathology, Myelin Basic Protein immunology, Myelin Basic Protein toxicity, Myelin Proteolipid Protein, Myelin-Oligodendrocyte Glycoprotein, Peptide Fragments immunology, Peptide Fragments toxicity, Spinal Cord pathology, Time Factors, Antibodies immunology, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental immunology, Multiple Sclerosis, Relapsing-Remitting immunology, T-Lymphocytes immunology
Abstract

To characterize T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis (RR-EAE), we compared myelin oligodendrocyte glycoprotein (MOG)-induced RR-EAE in C57BL/6 (B6) x SJL (F1) mice and chronic-progressive EAE (CP-EAE) in B6 mice at week 8 p.i. when clinical scores were comparable. Although these two strains exhibited similar inflammation/demyelination pattern and MOG-induced T cell responses, RR-EAE mice produced significantly higher levels of anti-MOG IgG1/IgG2a antibodies. Further, lymphocytes of RR-EAE mice proliferated vigorously to the secondary epitope myelin basic protein (MBP) 1-11. These results support a potential involvement of anti-MOG antibodies and epitope spreading in T cell responses in the development of MOG-induced RR-EAE model.

Published
2004
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