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Your search keyword '"S. Nischwitz"' showing total 4 results
Start Over Author "S. Nischwitz" Journal journal of neuroimmunology
4 results on '"S. Nischwitz"'

1. MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene

Author

Thomas Bettecken, Frank Weber, Uwe K. Zettl, P. Rieckmann, S. Nischwitz, Christiane Wolf, Marcus Ising, Bertram Mueller-Myhsok, Dorothea Buck, Darina Czamara, and Till F. M. Andlauer

Subjects
Adult, Male, Multiple Sclerosis, Adolescent, Genotype, Immunology, Single-nucleotide polymorphism, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, Young Adult, WFDC2, Meta-Analysis as Topic, Germany, medicine, Immunology and Allergy, Humans, Genetic Predisposition to Disease, Gene, Aged, Genetics, Aged, 80 and over, Multiple sclerosis, Middle Aged, medicine.disease, Molecular biology, SNP genotyping, body regions, Neurology, Matrix Metalloproteinase 9, Female, Neurology (clinical), Imputation (genetics), Genome-Wide Association Study
Abstract

Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, followed by imputation of SNPs within a region stretching 2Mbp up- and down-stream of MMP9. Rs6073751, located within WFDC2, was found associated with MS most strongly. Rs3918242, associated with MS according to previous reports, showed nominal significance only. Meta-analysis of our own and published data did not confirm this effect.

Published
2014

2. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis

Author

Marcus Ising, Thomas Bettecken, Felix Müller-Sarnowski, Bertram Müller-Myhsok, Hildegard Pfister, Florian Holsboer, Frank Weber, Sabine Cepok, Manfred Uhr, Bernhard Hemmer, D. Roeske, M. Knop, Antje Kroner, Peter Rieckmann, S. Nischwitz, and Christiane Wolf

Subjects
Adult, Male, Multiple Sclerosis, Adolescent, Immunology, Single-nucleotide polymorphism, Genome-wide association study, Human leukocyte antigen, Biology, Genome, Polymorphism, Single Nucleotide, Young Adult, HLA Antigens, Genetic variation, medicine, Immunology and Allergy, Humans, Genetic Predisposition to Disease, Proto-Oncogene Proteins c-vav, Gene, Aged, Genetics, Multiple sclerosis, Zinc Fingers, Middle Aged, medicine.disease, Histocompatibility, Repressor Proteins, Neurology, Case-Control Studies, Female, Neurology (clinical), Genome-Wide Association Study
Abstract

In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433.

Published
2009

3. MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene.

Author

Nischwitz S, Wolf C, Andlauer TF, Czamara D, Zettl UK, Rieckmann P, Buck D, Ising M, Bettecken T, Mueller-Myhsok B, and Weber F

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Female, Genome-Wide Association Study, Genotype, Germany, Humans, Male, Meta-Analysis as Topic, Middle Aged, Young Adult, Genetic Predisposition to Disease, Matrix Metalloproteinase 9 genetics, Multiple Sclerosis genetics, Polymorphism, Single Nucleotide genetics
Abstract

Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, followed by imputation of SNPs within a region stretching 2Mbp up- and down-stream of MMP9. Rs6073751, located within WFDC2, was found associated with MS most strongly. Rs3918242, associated with MS according to previous reports, showed nominal significance only. Meta-analysis of our own and published data did not confirm this effect., (Copyright © 2015 Elsevier B.V. All rights reserved.)

Published
2015
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4. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.

Author

Nischwitz S, Cepok S, Kroner A, Wolf C, Knop M, Müller-Sarnowski F, Pfister H, Roeske D, Rieckmann P, Hemmer B, Ising M, Uhr M, Bettecken T, Holsboer F, Müller-Myhsok B, and Weber F

Subjects
Adolescent, Adult, Aged, Case-Control Studies, Female, Genome-Wide Association Study methods, HLA Antigens genetics, Humans, Male, Middle Aged, Multiple Sclerosis epidemiology, Polymorphism, Single Nucleotide genetics, Young Adult, Genetic Predisposition to Disease genetics, Multiple Sclerosis genetics, Multiple Sclerosis metabolism, Proto-Oncogene Proteins c-vav genetics, Repressor Proteins genetics, Zinc Fingers genetics, Zinc Fingers immunology
Abstract

In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433., (Copyright © 2010 Elsevier B.V. All rights reserved.)

Published
2010
Full Text
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