1. Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infection.
- Author
-
Kim BJ, Kayembe K, Simecka JW, Pulse M, and Jones HP
- Subjects
- Animals, Cells, Cultured, Disease Models, Animal, Female, Immunity, Innate immunology, Mice, Mice, Inbred Strains, Pneumococcal Infections psychology, Sepsis immunology, Sepsis prevention & control, Sepsis psychology, Severity of Illness Index, Stress, Psychological immunology, CRF Receptor, Type 1, Pneumococcal Infections immunology, Receptors, Corticotropin-Releasing Hormone antagonists & inhibitors, Receptors, Corticotropin-Releasing Hormone physiology, Streptococcus pneumoniae immunology
- Abstract
Utilizing a murine model of S. pneumoniae infection and restraint stress, we determined how corticotropin releasing hormone (CRH-R) receptors impacts disease. CRH-R1 (antalarmin) and CRH-R2 (astressin2B) antagonists were administered intraperitoneally prior to restraint stress followed by pulmonary S. pneumoniae infection. CRH-R1 inhibition is not protective against pneumococcal disease induced by stress. Conversely, CRH-R2 inhibition attenuates stress-induced bacterial growth and significantly prevented severe sepsis. Neutrophillic responses were associated with CRH receptor-specific disease outcome providing a potential cellular target for stress-induced susceptibility to the development of severe pneumococcal disease. CRH receptor-mediated effects on immune responses could prove valuable for novel therapeutics., (Published by Elsevier B.V.)
- Published
- 2011
- Full Text
- View/download PDF