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Start Over Author "Dessi, M" Journal journal of neuroimmunology
3 results on '"Dessi, M"'

3. Determination of κFLC and κ Index in cerebrospinal fluid: a valid alternative to assess intrathecal immunoglobulin synthesis.

Author

Duranti F, Pieri M, Centonze D, Buttari F, Bernardini S, and Dessi M

Subjects
Adult, Aged, Biomarkers blood, Biomarkers cerebrospinal fluid, Female, Humans, Immunoglobulin kappa-Chains blood, Injections, Spinal, Male, Middle Aged, Multiple Sclerosis diagnosis, Reproducibility of Results, Severity of Illness Index, Young Adult, Immunoglobulin kappa-Chains biosynthesis, Immunoglobulin kappa-Chains cerebrospinal fluid, Multiple Sclerosis cerebrospinal fluid, Multiple Sclerosis immunology, Oligoclonal Bands biosynthesis, Oligoclonal Bands blood, Oligoclonal Bands cerebrospinal fluid
Abstract

Intrathecal immunoglobulin synthesis is observed in several disorders of the central nervous system, but its detection by current laboratory tests is relatively insensitive and operator depending. We assessed the diagnostic accuracy of a nephelometric assay for k free light chain determination in cerebrospinal fluid and serum. The patients were grouped according to clinical and laboratory criteria. ROC curves for all methods were performed to find the best cut-off value. kFLC Index seems to be more accurate than other parameters. Our data indicate that nephelometric assay for kFLCs in CSF reliably detect intrathecal immunoglobulin synthesis and discriminate multiple sclerosis patients., (© 2013.)

Published
2013
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