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Your search keyword '"Caldano, M."' showing total 2 results
Start Over Author "Caldano, M." Journal journal of neuroimmunology
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2. Anti-interferon-beta neutralising activity is not entirely mediated by antibodies.

Author

Gilli F, Marnetto F, Caldano M, Valentino P, Granieri L, Di Sapio A, Capobianco M, Sala A, Malucchi S, Kappos L, Lindberg RL, and Bertolotto A

Subjects
Case-Control Studies, Enzyme-Linked Immunosorbent Assay methods, Female, Follow-Up Studies, GTP-Binding Proteins genetics, GTP-Binding Proteins metabolism, Gene Expression drug effects, Humans, Immunoprecipitation, In Vitro Techniques, Male, Multiple Sclerosis therapy, Myxovirus Resistance Proteins, Neutralization Tests, Receptors, Interferon metabolism, Retrospective Studies, Antibodies therapeutic use, Interferon-beta immunology, Interferon-beta therapeutic use, Multiple Sclerosis immunology
Abstract

Many multiple sclerosis (MS) patients treated with interferon-beta (IFNbeta) develop anti-IFNbeta antibodies (BAbs), which can interfere with both in vitro and in vivo bioactivity of the injected cytokine. Objective of this study was to correlate these measures. Among the 256 enrolled patients, 11 (4.3%) showed a significant inhibition of the IFNbeta activity in vitro, but no measurable BAbs. As a whole, in vivo bioactivity was inhibited in 9/11 (82%) of these patients. A minority of IFNbeta treated patients have a non-antibody mediated neutralising activity, which competitively inhibits the bioactivity both in vitro and in vivo.

Published
2007
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