1. Viral Infections of the Central Nervous System: Pathogenesis to Therapeutics
- Author
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Steven Jacobson and Samantha S. Soldan
- Subjects
Pharmacology ,0303 health sciences ,Multiple sclerosis ,Neurodegeneration ,Central nervous system ,Immunology ,Neurotoxicity ,Neuroscience (miscellaneous) ,Biology ,medicine.disease ,Bioinformatics ,Article ,3. Good health ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,medicine ,Immunology and Allergy ,Neuropathogenesis ,Neurovirology ,030217 neurology & neurosurgery ,Neuroinflammation ,030304 developmental biology - Abstract
Viral infections of the CNS have been implicated in many debilitating illnesses including chronic neurodegenerative and neuroinflammatory disorders, neuropsychiatric conditions, acute encephalitis, and CNS malignancies. Although the effects of these manifold diseases are devastating, leading to death in some instances, the armamentarium of effective vaccines and therapeutics at our disposal to prevent and treat virus-mediated disorders of the CNS is astoundingly limited. It is, therefore, critical that we achieve a better understanding of the common mechanisms of neuroinflammation and neurodegeneration involved in these disorders so that more effective therapeutics can be developed. In this special issue of the Journal of Neuro-immune Pharmacology, we have assembled an extraordinary collection of contributions, including both comprehensive reviews and primary research articles, from leaders in the field of neurovirology. The manuscripts contained herein focus on a variety of CNS diseases caused by or associated with viruses from disparate families and highlight virus-induced mechanisms of neuropathogenesis supported by both clinical and basic research findings. Ultimately, the elucidation of pathways of virus-mediated neurotoxicity and the neuroinflammatory processes underlying these various conditions will lead to the development of treatment strategies for heterogenous disorders of the CNS associated with viral infection.
- Published
- 2010
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