1. Mosapride Accelerates the Delayed Gastric Emptying of High-Viscosity Liquids: A Crossover Study Using Continuous Real-Time 13C Breath Test (BreathID System)
- Author
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Sakamoto, Yasunari, Sekino, Yusuke, Yamada, Eiji, Ohkubo, Hidenori, Higurashi, Takuma, Sakai, Eiji, Iida, Hiroshi, Hosono, Kunihiro, Endo, Hiroki, Nonaka, Takashi, Ikeda, Tamon, Fujita, Koji, Yoneda, Masato, Koide, Tomoko, Takahashi, Hirokazu, Goto, Ayumu, Abe, Yasunobu, Gotoh, Eiji, Maeda, Shin, Nakajima, Atsushi, and Inamori, Masahiko
- Subjects
Mosapride ,digestive, oral, and skin physiology ,Original Article ,Gastric emptying ,Pectin ,Breath test - Abstract
Background/Aims The administration of liquid nutrients to patients is often accompanied by complications such as gastroesophageal reflux. To prevent gastroesophageal reflux, high-viscosity liquid meals are used widely, however, it still remains controversial whether high-viscosity liquid meals have any effect on the rate of gastric emptying. The present study was conducted with the aim of determining whether high-viscosity liquid meals had any effect on the rate of gastric emptying and mosapride might accelerate the rate of gastric emptying of high-viscosity liquid meals. Methods Six healthy male volunteers underwent 3 tests at intervals of > 1 week. After fasting for > 8 hours, each subject received one of three test meals (liquid meal only, high-viscosity liquid meal [liquid meal plus pectin] only, or high-viscosity liquid meal 30 minutes after intake of mosapride). A 13C-acetic acid breath test was performed, which monitored the rate of gastric emptying for 4 hours. Using the Oridion Research Software (β version), breath test parameters were calculated. The study parameters were examined for all the 3 test conditions and compared using the Freidman test. Results Gastric emptying was significantly delayed following intake of a high-viscosity liquid meal alone as compared with a liquid meal alone; however, intake of mosapride prior to a high-viscosity liquid meal was associated with a significantly accelerated rate of gastric emptying as compared with a high-viscosity liquid meal alone. Conclusions This study showed that high-viscosity liquid meals delayed gastric emptying: however, mosapride recovered the delayed rate of gastric emptying by high-viscosity liquid meals.
- Published
- 2011