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Your search keyword '"Sasaki, Hikaru"' showing total 17 results
Start Over Author "Sasaki, Hikaru" Journal journal of neuro-oncology
17 results on '"Sasaki, Hikaru"'

6. JCOG0911 INTEGRA study: a randomized screening phase II trial of interferonβ plus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma

Author

Wakabayashi, Toshihiko, Natsume, Atsushi, Mizusawa, Junki, Katayama, Hiroshi, Fukuda, Haruhiko, Sumi, Minako, Nishikawa, Ryo, Narita, Yoshitaka, Muragaki, Yoshihiro, Maruyama, Takashi, Ito, Tamio, Beppu, Takaaki, Nakamura, Hideo, Kayama, Takamasa, Sato, Shinya, Nagane, Motoo, Mishima, Kazuhiko, Nakasu, Yoko, Kurisu, Kaoru, Yamasaki, Fumiyuki, Sugiyama, Kazuhiko, Onishi, Takanori, Iwadate, Yasuo, Terasaki, Mizuhiko, Kobayashi, Hiroyuki, Matsumura, Akira, Ishikawa, Eiichi, Sasaki, Hikaru, Mukasa, Akitake, Matsuo, Takayuki, Hirano, Hirofumi, Kumabe, Toshihiro, Shinoura, Nobusada, Hashimoto, Naoya, Aoki, Tomokazu, Asai, Akio, Abe, Tatsuya, Yoshino, Atsuo, Arakawa, Yoshiki, Asano, Kenichiro, Yoshimoto, Koji, Shibui, Soichiro, and Members of Japan Clinical Oncology Group Brain Tumor Study Group (JCOG-BTSG)

Published
2018
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15. Prediction of genetic subgroups in adult supra tentorial gliomas by pre- and intraoperative parameters

Author

Nakae, Shunsuke, primary, Murayama, Kazuhiro, additional, Sasaki, Hikaru, additional, Kumon, Masanobu, additional, Nishiyama, Yuya, additional, Ohba, Shigeo, additional, Adachi, Kazuhide, additional, Nagahisa, Shinya, additional, Hayashi, Takuro, additional, Inamasu, Joji, additional, Abe, Masato, additional, Hasegawa, Mitsuhiro, additional, and Hirose, Yuichi, additional

Published
2016
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16. Histopathological vascular investigation of the peritumoral brain zone of glioblastomas.

Author

Tamura, Ryota, Ohara, Kentaro, Sasaki, Hikaru, Morimoto, Yukina, Yoshida, Kazunari, and Toda, Masahiro

Abstract

To date, no histopathological vascular investigation focusing on peritumoral brain zone (PBZ) has been reported for glioblastoma. We analyzed 10 newly diagnosed cases of glioblastomas. For these PBZs, histopathological investigation was performed by hematoxylin-eosin (H&E) staining and immunohistochemistry was analyzed for CD31, CD34, Factor VIII, VEGF, VEGFR-1/2, Ki67, p53 and nestin. Although it was difficult to identify PBZ by H&E, Ki67 and p53 staining, there were apparent differences in nestin staining among PBZ, tumor core (TC), and normal zone (NZ). Therefore, in this study, we divided PBZ from TC and NZ by nestin staining. Differences in histological features, microvessel density, expression of VEGF and its receptors were assessed for PBZ, TC and NZ. The microvessel density, as determined by counting CD31, CD34 and VEGF receptors, and VEGF-A expression were lower in PBZ than TC. The expression patterns for CD31, CD34 and VEGF receptors in vessels show dissociation in PBZ. In addition, the vascular characteristics of the PBZ may correlate with findings of radiographic imaging. We provide the first clinicopathological evidence that PBZ exhibits unique angiogenic characteristics. These in situ observations will help to elucidate the mechanisms of tumor recurrence. [ABSTRACT FROM AUTHOR]

Published
2018
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