Search

Your search keyword '"Mazzone, Paolo"' showing total 1 results
Start Over Author "Mazzone, Paolo" Topic basal ganglia Publication Year Range Last 50 years Journal journal of neural transmission
1 results on '"Mazzone, Paolo"'

1. Low frequency stimulation of the pedunculopontine nucleus modulates electrical activity of subthalamic neurons in the rat.

Author

Capozzo, Annamaria, Florio, Tiziana, Confalone, Giuseppina, Minchella, Daniela, Mazzone, Paolo, and Scarnati, Eugenio

Subjects
BRAIN stimulation, ELECTRIC stimulation, PARKINSON'S disease, LABORATORY rats, NEURONS
Abstract

Electrical stimulation of the rat pedunculopontine nucleus (PPTg) (<25 Hz) synchronized firing of subthalamic neurons (STN) with each stimulus, and a continuous irregular activity often preceded recovery of burst discharges in control as well as in 6-hydroxydopamine lesioned animals. Firing was blocked both by increasing frequency of stimulation (>50 Hz) and current intensity (>500 µA). The data suggest that clinically relevant frequencies for PPTg deep brain stimulation in Parkinson’s disease modulate burst discharges in STN neurons. [ABSTRACT FROM AUTHOR]

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results