1. The aging kidney: structural changes.
- Author
-
Pannarale G, Carbone R, Del Mastro G, Gallo C, Gattullo V, Natalicchio L, Navarra A, and Tedesco A
- Subjects
- Age Factors, Animals, Cellular Senescence, Glomerular Filtration Rate, Humans, Kidney blood supply, Kidney physiopathology, Kidney Diseases pathology, Kidney Diseases physiopathology, Kidney Glomerulus pathology, Kidney Glomerulus physiopathology, Kidney Tubules pathology, Kidney Tubules physiopathology, Renal Artery pathology, Renal Artery physiopathology, Renal Circulation, Risk Factors, Aging pathology, Kidney pathology, Kidney Diseases etiology
- Abstract
A number of structural changes occur in the kidney with aging. The aging kidney is characterized by loss of renal mass, arterial sclerosis, arteriolar hyalinosis, an increased number of sclerotic glomeruli, loss of tubules and interstitial fibrosis. The pathogenesis of aging-associated structural changes is not completely understood. Both genetic background and hemodynamic factors have been associated with progression of age-related morphological changes. The structural changes of aging kidney are nonspecific and can be seen in many conditions, including diabetes and hypertension, and, as such, arterionephrosclerosis of aging is a diagnosis of exclusion.
- Published
- 2010