Author: "de Pedro, Nuria" / Journal: journal of natural products - Searchworks@Jio Institute Digital Library Search Results

Author: Almeida, Celso, primary, Pérez-Victoria, Ignacio, additional, González-Menéndez, Víctor, additional, de Pedro, Nuria, additional, Martín, Jesús, additional, Crespo, Gloria, additional, Mackenzie, Thomas, additional, Cautain, Bastien, additional, Reyes, Fernando, additional, Vicente, Francisca, additional, and Genilloud, Olga, additional
Published: 2018
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Author: Pérez-Bonilla, Mercedes, primary, González-Menéndez, Víctor, additional, Pérez-Victoria, Ignacio, additional, de Pedro, Nuria, additional, Martín, Jesús, additional, Molero-Mesa, Joaquín, additional, Casares-Porcel, Manuel, additional, González-Tejero, María Reyes, additional, Vicente, Francisca, additional, Genilloud, Olga, additional, Tormo, José R., additional, and Reyes, Fernando, additional
Published: 2017
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Author: Angulo-Preckler, Carlos, primary, Genta-Jouve, Grégory, additional, Mahajan, Nipun, additional, de la Cruz, Mercedes, additional, de Pedro, Nuria, additional, Reyes, Fernando, additional, Iken, Katrin, additional, Avila, Conxita, additional, and Thomas, Olivier P., additional
Published: 2016
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Author: Almeida, Celso, Pérez-Victoria, Ignacio, González-Menéndez, Víctor, de Pedro, Nuria, Martín, Jesús, Crespo, Gloria, Mackenzie, Thomas, Cautain, Bastien, Reyes, Fernando, Vicente, Francisca, and Genilloud, Olga
Abstract: Two new epimeric dihalogenated diaporthins, (9R*)-8-methyl-9,11-dichlorodiaporthin (2) and (9S*)-8-methyl-9,11-dichlorodiaporthin (3), have been isolated from the soil fungus Hamigera fuscaNRRL 35721 alongside the known regioisomeric isocoumarin 8-methyl-11,11-dichlorodiaporthin (1). Their structures were elucidated by high-resolution mass spectrometry and NMR spectroscopy combined with molecular modeling. Compounds 1–3are the first isocoumarins and the first halogenated metabolites ever reported from the Hamigeragenus. The new compounds 2and 3display a non-geminal aliphatic dichlorination pattern unprecedented among known fungal dihalogenated aromatic polyketides. A bifunctional methyltransferase/aliphatic halogenase flavoenzyme is proposed to be involved in the biosynthesis of dichlorinated diaporthins 1–3. These metabolites are weakly cytotoxic.
Published: 2018
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Author: Pérez-Victoria, Ignacio, primary, Martín, Jesús, additional, González-Menéndez, Víctor, additional, de Pedro, Nuria, additional, El Aouad, Noureddine, additional, Ortiz-López, Francisco Javier, additional, Tormo, José Rubén, additional, Platas, Gonzalo, additional, Vicente, Francisca, additional, Bills, Gerald F., additional, Genilloud, Olga, additional, Goetz, Michael A., additional, and Reyes, Fernando, additional
Published: 2012
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Author: Pérez-Bonilla, Mercedes, González-Menéndez, Víctor, Pérez-Victoria, Ignacio, de Pedro, Nuria, Martín, Jesús, Molero-Mesa, Joaquín, Casares-Porcel, Manuel, González-Tejero, María Reyes, Vicente, Francisca, Genilloud, Olga, Tormo, José R., and Reyes, Fernando
Abstract: A search for cytotoxic agents from cultures of the endophytic fungus Dothiorasp., isolated from the endemic plant Launaea arborescens, led to the isolation of six new compounds structurally related to hormonemate, with moderate cytotoxic activity against different cancer cell lines. By using a bioassay-guided fractionation approach, hormonemates A–D (1–4), hormonemate (5), and hormonemates E (6) and F (7) were obtained from the acetone extract of this fungus. Their structures were determined using a combination of HRMS, ESI-qTOF-MS/MS, 1D and 2D NMR experiments, and chemical degradation. The cytotoxic activities of these compounds were evaluated by microdilution colorimetric assays against human breast adenocarcinoma (MCF-7), human liver cancer cells (HepG2), and pancreatic cancer cells (MiaPaca_2). Most of the compounds displayed cytotoxic activity against this panel.
Published: 2017
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