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Start Over Author "Zhang, Yan-Li" Journal journal of natural products
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4. Diterpenoids fromIsodonmelissoides

Author

Zhao, Ai-Hua, primary, Han, Quan-Bin, additional, Li, Rong-Tao, additional, Li, Sheng-Hong, additional, Qing, Chen, additional, Zhang, Yan-Li, additional, Zhao, Qin-Shi, additional, Wang, Fu-Sheng, additional, and Sun, Han-Dong, additional

Published
2004
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5. Diterpenoids from Isodon melissoides.

Author

Zhao AH, Han QB, Li RT, Li SH, Qing C, Zhang YL, Zhao QS, Wang FS, and Sun HD

Subjects
Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, China, Diterpenes chemistry, Diterpenes pharmacology, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Stereoisomerism, Tumor Cells, Cultured, Antineoplastic Agents, Phytogenic isolation & purification, Diterpenes isolation & purification, Isodon chemistry, Plants, Medicinal chemistry
Abstract

Nine new diterpenoids, melissoidesins M-U (1-9), along with five known analogues, melissoidesin F (10), xindongnin B (11), melissoidesin G (12), melissoidesin E (13), and dawoensin A (14), were isolated from the aerial parts of Isodon melissoides. The structures of new compounds were elucidated by analysis of spectral evidence including extensive 2D NMR data. Compounds 2, 3, 7, 11, 12, and 14 showed cytotoxicity against the human tumor BGC-823 cell line with IC(50) values less than 10 microg/mL, respectively.

Published
2004
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