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Your search keyword '"Xu, Xin-Ya"' showing total 4 results
Start Over Author "Xu, Xin-Ya" Journal journal of natural products
4 results on '"Xu, Xin-Ya"'

3. Nahuoic Acids B–E, Polyhydroxy Polyketides from the Marine-Derived Streptomycessp. SCSGAA 0027

Author

Nong, Xu-Hua, Zhang, Xiao-Yong, Xu, Xin-Ya, Wang, Jie, and Qi, Shu-Hua

Abstract

Four new polyol polyketides containing a decalin ring, nahuoic acids B–E (1–4), together with a known analogue, nahuoic acid A (5), possessing an unprecedented carbon skeleton, were isolated from a culture broth of the marine-derived Streptomycessp. SCSGAA 0027. Their structures were determined by detailed analysis of spectroscopic data and chemical transformations including acetonide formation and Mosher’s ester method. Compounds 1–5showed weak antibiofilm activity against Shewanella onedensisMR-1 biofilm. This is the first series of analogues of the novel selective SETD8 inhibitor nahuoic acid A.

Published
2016
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4. Nahuoic Acids B-E, Polyhydroxy Polyketides from the Marine-Derived Streptomyces sp. SCSGAA 0027.

Author

Nong XH, Zhang XY, Xu XY, Wang J, and Qi SH

Subjects
Biofilms drug effects, Histone-Lysine N-Methyltransferase antagonists & inhibitors, Marine Biology, Microbial Sensitivity Tests, Nuclear Magnetic Resonance, Biomolecular, Polyketides chemistry, Polyketides pharmacology, Shewanella drug effects, Polyketides isolation & purification, Streptomyces chemistry
Abstract

Four new polyol polyketides containing a decalin ring, nahuoic acids B-E (1-4), together with a known analogue, nahuoic acid A (5), possessing an unprecedented carbon skeleton, were isolated from a culture broth of the marine-derived Streptomyces sp. SCSGAA 0027. Their structures were determined by detailed analysis of spectroscopic data and chemical transformations including acetonide formation and Mosher's ester method. Compounds 1-5 showed weak antibiofilm activity against Shewanella onedensis MR-1 biofilm. This is the first series of analogues of the novel selective SETD8 inhibitor nahuoic acid A.

Published
2016
Full Text
View/download PDF

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