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Your search keyword '"Weng, Zhi"' showing total 4 results
Start Over Author "Weng, Zhi" Journal journal of natural products
4 results on '"Weng, Zhi"'

1. Bioactive Nortriterpenoids from Schisandra grandiflora

Author

Xiao, Wei-Lie, primary, Gong, Yan-Qing, additional, Wang, Rui-Rui, additional, Weng, Zhi-Ying, additional, Luo, Xiao, additional, Li, Xiao-Nian, additional, Yang, Guang-Yu, additional, He, Fei, additional, Pu, Jian-Xin, additional, Yang, Liu-Meng, additional, Zheng, Yong-Tang, additional, Lu, Yang, additional, and Sun, Han-Dong, additional

Published
2009
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3. Cytotoxic ent-Kauranoids from the Medicinal Plant Isodon xerophilus

Author

Li, Li-Mei, Weng, Zhi-Ying, Huang, Sheng-Xiong, Pu, Jian-Xin, Li, Sheng-Hong, Huang, Hao, Yang, Bing-Bing, Han, Yu, Xiao, Wei-Lie, Li, Ma-Lin, Han, Quan-Bin, and Sun, Han-Dong

Abstract

Bioassay-directed fractionation of the leaves of the medicinal plant Isodon xerophilusled to the isolation of a series of potential antitumor molecules. Thirteen new (1−13) and 23 (14−36) known diterpenoids were isolated and identified, representing ent-kauranoids of several structural types. The structures of 1−13were determined by means of spectroscopic studies. The absolute configurations of the new compounds were clarified by CD spectroscopic studies or were postulated on biogenetic grounds. All compounds obtained were evaluated for their cytotoxic activity against the K562, MKN45, and HepG2 cell lines. Compounds 1, 2, 11, 16−19, 23, 26−28, 30, and 32demonstrated significant cytotoxic activity for one or more cell lines.

Published
2007
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4. Inhibition of NF-kappaB activation and iNOS induction by ent-kaurane diterpenoids in LPS-stimulated RAW264.7 murine macrophages.

Author

Aquila S, Weng ZY, Zeng YQ, Sun HD, and Ríos JL

Subjects
Animals, Anti-Inflammatory Agents, Non-Steroidal chemistry, Diterpenes chemistry, Diterpenes, Kaurane chemistry, Lipopolysaccharides pharmacology, Macrophages drug effects, Mice, Molecular Structure, NF-kappa B antagonists & inhibitors, NF-kappa B genetics, Nitric Oxide metabolism, Reverse Transcriptase Polymerase Chain Reaction, Anti-Inflammatory Agents, Non-Steroidal isolation & purification, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Diterpenes isolation & purification, Diterpenes pharmacology, Diterpenes, Kaurane isolation & purification, Diterpenes, Kaurane pharmacology, Isodon chemistry, Luciferases metabolism, Nitric Oxide Synthase Type II drug effects, Plants, Medicinal chemistry
Abstract

Xerophilusin A (1), xerophilusin B (2), longikaurin B (3), and xerophilusin F (4) from Isodon xerophylus inhibit LPS-induced NO production in RAW 264.7 macrophages, with IC(50) values of 0.60, 0.23, 0.44, and 0.67 muM, respectively, and they all inhibited mRNA production in these same cells. They decreased the luciferase activity in RAW 264.7 cells transiently transfected with the NF-kappaB-dependent luciferase reporter, with IC(50) values of 1.8, 0.7, 1.2, and 1.6 muM, respectively. Compounds 1-3 reduced NF-kappaB activation, with compound 4 showing no effect, but p65 translocation from the cytoplasm to the nucleus and the LPS-induced degradation of IkappaB were inhibited by all four test compounds. These findings indicate that ent-kauranes are potential anti-inflammatory agents, with a specific mechanism in which both the inhibition of NF-kappaB translocation and the consequent decrease of pro-inflammatory mediators are implicated.

Published
2009
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