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Your search keyword '"Tannis M. Jurgens"' showing total 2 results
Start Over Author "Tannis M. Jurgens" Journal journal of natural products
2 results on '"Tannis M. Jurgens"'

1. L-741,494, a fungal metabolite that is an inhibitor of interleukin-1 beta converting enzyme

Author

Jon D. Polishook, Russell B. Lingham, Claude Dufresne, Lin Kong, Gregory E. Koch, Isabel Martin, John G. Ondeyka, Jerrold M. Liesch, Tannis M. Jurgens, Ermenegilda McCauley, Hans T. Beck, Robert P. Borris, Carmen Cascales, Steven R. King, Otto D. Hensens, Susan L. Raghoobar, Fernando Pelaez, Michael J. Salvatore, Suzanne E. Gartner, Deborah L. Zink, Maria Teresa Diez, Michael J. Balick, and Amy Hsu

Subjects
Magnetic Resonance Spectroscopy, Stereochemistry, Metabolite, medicine.medical_treatment, Molecular Sequence Data, Pharmaceutical Science, Xylaria, Acetates, Analytical Chemistry, chemistry.chemical_compound, Drug Discovery, Mole, medicine, Amino Acid Sequence, Pharmacology, chemistry.chemical_classification, biology, Xylariales, Organic Chemistry, Caspase 1, Metalloendopeptidases, biology.organism_classification, Trypsin, Chromatography, Ion Exchange, Papain, Cysteine Endopeptidases, Cytokine, Enzyme, Complementary and alternative medicine, Biochemistry, chemistry, Enzyme inhibitor, Pyrones, biology.protein, Molecular Medicine, medicine.drug
Abstract

gamma-Pyrone-3-acetic acid (L-741,494) is a novel metabolite produced by a culture of the fungal genus Xylaria. This substance is a water-soluble, competitive, irreversible inhibitor of Interleukin-1 beta Converting Enzyme that is inactive against papain and trypsin. It has a mol wt of 154 and an empirical formula of C7H6O4. We propose the name xylaric acid for this compound.

Published
1994

2. Novel nematocidal agents from Curcuma comosa

Author

Deborah L. Zink, Easter G. Frazier, Michael J. Balick, Hans T. Beck, James M. Schaeffer, Tracey E. Jones, Tannis M. Jurgens, Robert P. Borris, and Weerachai Nanakorn

Subjects
Pharmacology, Folk medicine, Curcumin, Magnetic Resonance Spectroscopy, biology, Nematode caenorhabditis elegans, Plant Extracts, Antinematodal Agents, Organic Chemistry, Pharmaceutical Science, Curcuma comosa, Plants, biology.organism_classification, Mass Spectrometry, Analytical Chemistry, Complementary and alternative medicine, Drug Discovery, Botany, Natural source, Molecular Medicine, Animals, Zingiberaceae, Spectrophotometry, Ultraviolet, Caenorhabditis elegans
Abstract

Curcuma comosa is a member of the economically important plant family, Zingiberaceae. A methanolic extract of C. comosa was shown to be nematocidal when tested against the free-living nematode Caenorhabditis elegans. Five diphenylheptanoids [1-5], one new and four known, have been isolated and shown to be responsible for the activity. This is the first report of three of these compounds [1, 2, 4] being isolated from a natural source.

Published
1994

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