Search

Your search keyword '"Tang, Gui-Hua"' showing total 21 results
Start Over Author "Tang, Gui-Hua" Journal journal of natural products
21 results on '"Tang, Gui-Hua"'

7. Cytotoxic Amide Alkaloids from Piper boehmeriaefolium

Author

Tang, Gui-Hua, Chen, Dong-Mei, Qiu, Bei-Ying, Sheng, Li, Wang, Yue-Hu, Hu, Guang-Wan, Zhao, Fu-Wei, Ma, Li-Juan, Wang, Huan, Huang, Qiao-Qin, Xu, Jin-Jin, Long, Chun-Lin, and Li, Jia

Abstract

Eight new amide alkaloids (1−8) and 19 known ones were isolated from the whole plant of Piper boehmeriaefolium. Their structures were determined through spectroscopic data analyses. Cytotoxic activity of these amides against human cervical carcinoma HeLa cells was evaluated, and 1-[(9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl]pyrrolidine (9) exhibited significant inhibitory activity with an IC50value of 2.7 μg/mL.

Published
2024
Full Text
View/download PDF

12. Euphorhelipanes A and B, Triglyceride-Lowering EuphorbiaDiterpenoids with a Bicyclo[4.3.0]nonane Core from Euphorbia helioscopia

Author

Li, Wei, Tang, Ya-Qi, Chen, Shi-Xin, Tang, Gui-Hua, Gan, Li-She, Li, Chan, Rao, Yong, Huang, Zhi-Shu, and Yin, Sheng

Abstract

Euphorhelipanes A (1) and B (2), two Euphorbiaditerpenoids with a new 4-(5,5-dimethylheptan-2-yl)-2,7-dimethylbicyclo[4.3.0]nonane skeleton, were isolated from a 95% ethanol extract of the whole plants of Euphorbia helioscopia. Their structures were elucidated by spectroscopic data analysis, quantum chemical calculations, and single-crystal X-ray diffraction data. Compounds 1and 2represent the first examples of Euphorbiaditerpenoids with a 5/6 fused carbon ring system, and their plausible biosynthetic pathways originating from jatrophanes are proposed. Compounds 1and 2showed a triglyceride-lowering effect in oleic-acid-stimulated HuH7 cells at concentrations of 1–50 μM.

Published
2019
Full Text
View/download PDF

13. Bioactive Limonoid and Triterpenoid Constituents of Turraea pubescens

Author

Yuan, Chun-Mao, primary, Tang, Gui-Hua, additional, Zhang, Yu, additional, Wang, Xiao-Ying, additional, Cao, Ming-Ming, additional, Guo, Feng, additional, Li, Yan, additional, Di, Ying-Tong, additional, Li, Shun-Lin, additional, Hua, Hui-Ming, additional, He, Hong-Ping, additional, and Hao, Xiao-Jiang, additional

Published
2013
Full Text
View/download PDF

14. Khayseneganins A–H, Limonoids from Khaya senegalensis

Author

Yuan, Chun-Mao, primary, Zhang, Yu, additional, Tang, Gui-Hua, additional, Di, Ying-Tong, additional, Cao, Ming-Ming, additional, Wang, Xiao-Ying, additional, Zuo, Guo-Ying, additional, Li, Shun-Lin, additional, Hua, Hui-Ming, additional, He, Hong-Ping, additional, and Hao, Xiao-Jiang, additional

Published
2012
Full Text
View/download PDF

17. Cytotoxic Amide Alkaloids from Piper boehmeriaefolium

Author

Tang, Gui-Hua, primary, Chen, Dong-Mei, additional, Qiu, Bei-Ying, additional, Sheng, Li, additional, Wang, Yue-Hu, additional, Hu, Guang-Wan, additional, Zhao, Fu-Wei, additional, Ma, Li-Juan, additional, Wang, Huan, additional, Huang, Qiao-Qin, additional, Xu, Jin-Jin, additional, Long, Chun-Lin, additional, and Li, Jia, additional

Published
2010
Full Text
View/download PDF

19. Neolignans from Aristolochia fordianaPrevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells

Author

Tang, Gui-Hua, Chen, Zi-Wei, Lin, Ting-Ting, Tan, Min, Gao, Xiao-Yun, Bao, Jing-Mei, Cheng, Zhong-Bin, Sun, Zhang-Hua, Huang, Gang, and Yin, Sheng

Abstract

Bioassay-guided fractionation of the ethanolic extract of the stems of Aristolochia fordianaled to the isolation of six new dihydrobenzofuran neolignans (1–3and 7–9), three new 2-aryldihydrobenzofurans (4–6), a new 8-O-4′ neolignan (10), and 14 known analogues (11–24). The structures of compounds 1–10were established by spectroscopic methods, and their absolute configurations were determined by analyses of the specific rotation and electronic circular dichroism data. The neuroprotective effects of compounds 1–24against glutamate-induced cell death were tested in hippocampal neuronal cell line HT22. Compounds 17and 20–24exhibited moderate neuroprotective activity by increasing the endogenous antioxidant defense system. In addition, the neolignans activated the Nrf2 (nuclear factor E2-related factor 2) pathway, resulting in the increase of the expression of endogenous antioxidant protein HO-1 (heme oxygenase-1). The active compounds also preserved the levels of antiapoptotic protein Bcl-2 (B cell lymphoma/leukemia-2), which was decreased by glutamate. Collectively, these results suggested that the active neolignans protect neurons against glutamate-induced cell death through maintaining the Nrf2/HO-1 signaling pathway as well as preserving the Bcl-2 protein and might be promising novel beneficial agents for oxidative stress-associated diseases.

Published
2015
Full Text
View/download PDF

20. Khayseneganins A–H, Limonoids from Khaya senegalensis

Author

Yuan, Chun-Mao, Zhang, Yu, Tang, Gui-Hua, Di, Ying-Tong, Cao, Ming-Ming, Wang, Xiao-Ying, Zuo, Guo-Ying, Li, Shun-Lin, Hua, Hui-Ming, He, Hong-Ping, and Hao, Xiao-Jiang

Abstract

Eight new limonoids, khayseneganins A–H (1–8), and 31 known limonoids were isolated from the leaves and twigs of Khaya senegalensis. The structures of the new compounds were elucidated by 2D-NMR spectroscopy and mass spectrometry, and the absolute configuration of 1was determined by the CD exciton chirality method. Compounds 9, 10, 12, and 15showed antimicrobial activities against Pseudomonas aeruginosa, MRSA 92#, and MRSA 98#, all with a MIC value of 12.5 μg/mL.

Published
2013
Full Text
View/download PDF

21. Cytotoxic amide alkaloids from Piper boehmeriaefolium.

Author

Tang GH, Chen DM, Qiu BY, Sheng L, Wang YH, Hu GW, Zhao FW, Ma LJ, Wang H, Huang QQ, Xu JJ, Long CL, and Li J

Subjects
Alkaloids chemistry, Amides chemistry, Antineoplastic Agents, Phytogenic chemistry, Drug Screening Assays, Antitumor, Drugs, Chinese Herbal chemistry, Female, HeLa Cells, Humans, Inhibitory Concentration 50, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Pyrrolidines chemistry, Stereoisomerism, Alkaloids isolation & purification, Alkaloids pharmacology, Amides isolation & purification, Amides pharmacology, Antineoplastic Agents, Phytogenic isolation & purification, Antineoplastic Agents, Phytogenic pharmacology, Drugs, Chinese Herbal isolation & purification, Drugs, Chinese Herbal pharmacology, Piper chemistry, Pyrrolidines isolation & purification, Pyrrolidines pharmacology
Abstract

Eight new amide alkaloids (1-8) and 19 known ones were isolated from the whole plant of Piper boehmeriaefolium. Their structures were determined through spectroscopic data analyses. Cytotoxic activity of these amides against human cervical carcinoma HeLa cells was evaluated, and 1-[(9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl]pyrrolidine (9) exhibited significant inhibitory activity with an IC(50) value of 2.7 μg/mL.

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results