Search

Your search keyword '"Sun, Cheng-Peng"' showing total 11 results
Start Over Author "Sun, Cheng-Peng" Journal journal of natural products
11 results on '"Sun, Cheng-Peng"'

5. Uncarialins A–I, Monoterpenoid Indole Alkaloids from Uncaria rhynchophyllaas Natural Agonists of the 5-HT1AReceptor

Author

Liang, Jia-Hao, Luan, Zhi-Lin, Tian, Xiang-Ge, Zhao, Wen-Yu, Wang, Ya-Li, Sun, Cheng-Peng, Huo, Xiao-Kui, Deng, Sa, Zhang, Bao-Jing, Zhang, Zhan-Jun, and Ma, Xiao-Chi

Abstract

Nine new monoterpenoid indole alkaloids, uncarialins A–I (1–9), were isolated from Uncaria rhynchophyllaas well as 14 known analogues (10–23). Their structures were determined by HRESIMS, 1D and 2D NMR, and experimental and calculated electronic circular dichroism data. Compounds 5, 7, 15, and 22displayed significant agonistic effects against the 5-HT1Areceptor with EC50values of 2.2 ± 0.1, 0.1 ± 0.1, 1.6 ± 0.3, and 2.0 ± 0.5 μM, respectively. The mechanisms of action of these four compounds with the 5-HT1Areceptor were investigated by molecular docking, and the results suggested that amino acid residues Asp116, Thr196, Asn386, and Tyr390 played critical roles in the observed activity of the above-mentioned compounds.

Published
2019
Full Text
View/download PDF

7. ent-Abietane and Tigliane Diterpenoids from the Roots of Euphorbia fischerianaand Their Inhibitory Effects against Mycobacterium smegmatis

Author

Wang, Chun-Jie, Yan, Qiu-Long, Ma, Yu-Fang, Sun, Cheng-Peng, Chen, Chang-Ming, Tian, Xiang-Ge, Han, Xiu-Yan, Wang, Chao, Deng, Sa, and Ma, Xiao-Chi

Abstract

An investigation on the bioactive chemical constituents of the roots of Euphorbia fischerianahas been conducted, with 21 diterpenoids obtained using various chromatographic techniques. On the basis of spectroscopic data analysis, the new compounds were elucidated as four ent-abietane-type diterpenoids (1–4) and four tigliane-type diterpenoids (13–16). Also obtained were eight known ent-abietane (5–12) and five known tigliane (17–21) diterpenoids. The potential antituberculosis effects of these diterpenoids were evaluated using a Mycobacterium smegmatismodel. The most potent compound according to the in vitro bioassay used was 17-hydroxyjolkinolide B (12) (MIC 1.5 μg/mL).

Published
2017
Full Text
View/download PDF

11. Uncarialins A-I, Monoterpenoid Indole Alkaloids from Uncaria rhynchophylla as Natural Agonists of the 5-HT 1A Receptor.

Author

Liang JH, Luan ZL, Tian XG, Zhao WY, Wang YL, Sun CP, Huo XK, Deng S, Zhang BJ, Zhang ZJ, and Ma XC

Subjects
Animals, CHO Cells, Cricetulus, Molecular Docking Simulation, Molecular Structure, Secologanin Tryptamine Alkaloids chemistry, Secologanin Tryptamine Alkaloids isolation & purification, Serotonin Receptor Agonists chemistry, Serotonin Receptor Agonists isolation & purification, Spectrum Analysis methods, Receptor, Serotonin, 5-HT1A drug effects, Secologanin Tryptamine Alkaloids pharmacology, Serotonin Receptor Agonists pharmacology, Uncaria chemistry
Abstract

Nine new monoterpenoid indole alkaloids, uncarialins A-I ( 1 - 9 ), were isolated from Uncaria rhynchophylla as well as 14 known analogues ( 10 - 23 ). Their structures were determined by HRESIMS, 1D and 2D NMR, and experimental and calculated electronic circular dichroism data. Compounds 5 , 7 , 15 , and 22 displayed significant agonistic effects against the 5-HT 1A receptor with EC 50 values of 2.2 ± 0.1, 0.1 ± 0.1, 1.6 ± 0.3, and 2.0 ± 0.5 μM, respectively. The mechanisms of action of these four compounds with the 5-HT 1A receptor were investigated by molecular docking, and the results suggested that amino acid residues Asp116, Thr196, Asn386, and Tyr390 played critical roles in the observed activity of the above-mentioned compounds.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results