1. Novel Cytotoxic 4-Phenylfuranocoumarins from Calophyllum dispar
- Author
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Thierry Sevenet, Denis Seraphin, Jean-Jacques Helesbeux, J. Bruneton, David Guilet, and Pascal Richomme
- Subjects
Stereochemistry ,Dispar ,Pharmaceutical Science ,Pharmacognosy ,KB Cells ,Mass Spectrometry ,Plant Epidermis ,Analytical Chemistry ,Coumarins ,Drug Discovery ,Humans ,Cytotoxic T cell ,Calophyllum ,Pharmacology ,chemistry.chemical_classification ,Plants, Medicinal ,biology ,Traditional medicine ,Chemistry ,Organic Chemistry ,Biological activity ,biology.organism_classification ,Antineoplastic Agents, Phytogenic ,In vitro ,Complementary and alternative medicine ,Fruit ,visual_art ,visual_art.visual_art_medium ,Molecular Medicine ,Spectrophotometry, Ultraviolet ,Bark ,Drug Screening Assays, Antitumor ,Lactone - Abstract
Eight new 4-phenylfuranocoumarins (1-8) have been isolated from the stem bark and the fruits of Calophyllum dispar, together with three known coumarins. The structures of 1-8 were established by means of spectroscopic analysis, including extensive 2D NMR studies. Some of these furanocoumarins exhibited significant cytotoxic activity against KB cells.
- Published
- 2001
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