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Your search keyword '"Maneerat, Tharakorn"' showing total 3 results
Start Over Author "Maneerat, Tharakorn" Journal journal of natural products
3 results on '"Maneerat, Tharakorn"'

1. Tetrahydroxanthene-1,3(2H)-diones and Oxidized Hexadiene Derivatives from Uvaria leptopoda and Their Biological Activities

Author

Teerapongpisan, Passakorn, primary, Monkantha, Thanakorn, additional, Yimklan, Saranphong, additional, Mah, Siau Hui, additional, Gunter, Natalie Vivien, additional, Promnart, Phunrawie, additional, Deachathai, Suwanna, additional, Maneerat, Tharakorn, additional, Duangyod, Thidarat, additional, Charoensup, Rawiwan, additional, Baka, Abdulromea, additional, Andersen, Raymond J., additional, and Laphookhieo, Surat, additional

Published
2024
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2. Tetrahydroxanthene-1,3(2H)-diones and Oxidized Hexadiene Derivatives from Uvaria leptopodaand Their Biological Activities

Author

Teerapongpisan, Passakorn, Monkantha, Thanakorn, Yimklan, Saranphong, Mah, Siau Hui, Gunter, Natalie Vivien, Promnart, Phunrawie, Deachathai, Suwanna, Maneerat, Tharakorn, Duangyod, Thidarat, Charoensup, Rawiwan, Baka, Abdulromea, Andersen, Raymond J., and Laphookhieo, Surat

Abstract

The first phytochemical investigation of the twig extract of Uvaria leptopodaresulted in the isolation and identification of three new tetrahydroxanthene-1,3(2H)-diones, uvarialeptones A–C, two new oxidized hexadiene derivatives, uvarialeptols A and B, together with ten known compounds. Their structures were elucidated by spectroscopic techniques and mass spectrometry. Uvarialeptones A and B were unprecedented tetrahydroxanthene-1,3(2H)-dione dimers which exhibited a cyclobutane ring via [2 + 2] cycloaddition from uvarialeptone C and 9a-O-methyloxymitrone, respectively. The structure of uvarialeptone A was confirmed by X-ray diffraction analysis using Mo Kα radiation. Compound 3inhibited NO production at an IC50value of 6.7 ± 0.1 μM.

Published
2024
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3. Tetrahydroxanthene-1,3(2 H )-diones and Oxidized Hexadiene Derivatives from Uvaria leptopoda and Their Biological Activities.

Author

Teerapongpisan P, Monkantha T, Yimklan S, Mah SH, Gunter NV, Promnart P, Deachathai S, Maneerat T, Duangyod T, Charoensup R, Baka A, Andersen RJ, and Laphookhieo S

Subjects
Molecular Structure, Animals, Nitric Oxide biosynthesis, Mice, Xanthenes pharmacology, Xanthenes chemistry, Crystallography, X-Ray, Oxidation-Reduction, RAW 264.7 Cells, Uvaria chemistry
Abstract

The first phytochemical investigation of the twig extract of Uvaria leptopoda resulted in the isolation and identification of three new tetrahydroxanthene-1,3(2 H )-diones, uvarialeptones A-C, two new oxidized hexadiene derivatives, uvarialeptols A and B, together with ten known compounds. Their structures were elucidated by spectroscopic techniques and mass spectrometry. Uvarialeptones A and B were unprecedented tetrahydroxanthene-1,3(2 H )-dione dimers which exhibited a cyclobutane ring via [2 + 2] cycloaddition from uvarialeptone C and 9a- O -methyloxymitrone, respectively. The structure of uvarialeptone A was confirmed by X-ray diffraction analysis using Mo Kα radiation. Compound 3 inhibited NO production at an IC 50 value of 6.7 ± 0.1 μM.

Published
2024
Full Text
View/download PDF

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