1. Soularubinone, a new antileukemic quassionoid from Soulamea tomentosa.
- Author
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Van Tri M, Polonsky J, Merienne C, and Sevenet T
- Subjects
- Animals, Cell Transformation, Neoplastic drug effects, Chemical Phenomena, Chemistry, Physical, Glaucarubin analogs & derivatives, Glaucarubin pharmacology, Leukemia P388 drug therapy, Magnetic Resonance Spectroscopy, Mice, Antineoplastic Agents, Phytogenic analysis, Glaucarubin analysis, Phenanthrenes analysis, Quassins
- Abstract
The structure of soularubinone 3, a new antileukemic quassinoid isolated from the leaves of Soulamea tomentosa (Brongn, and Gris), has been established by spectral and chemical methods. It has been shown to be the C-15 beta-hydroxy-isovaleric ester of glaucarubolone. Soularubinone shows significant antineoplastic activity against mouse leukemia P-388 and inhibits cell transformation induced by Rous sarcoma virus. The known quassinoid chaparrinone I has also been isolated.
- Published
- 1981
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