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Your search keyword '"Ito, Michiho"' showing total 15 results
Start Over Author "Ito, Michiho" Journal journal of natural products
15 results on '"Ito, Michiho"'

3. Role of Ascaridole and p-Cymene in the Sleep-Promoting Effects of Dysphania ambrosioidesEssential Oil via the GABAergic System in a ddY Mouse Inhalation Model

Author

Dougnon, Godfried and Ito, Michiho

Abstract

The essential oil obtained from Dysphania ambrosioidesleaves (DAEO) has antifungal, antioxidant, and antimicrobial properties. This study investigated DAEO’s chemical composition and its sleep-promoting effects via administration by inhalation in ddY mice. Ascaridole (35.5%) and p-cymene (47.2%) were the major components. To obtain insight into DAEO’s effects on the central nervous system (CNS), ascaridole and p-cymene were evaluated for sedative activity by using the caffeine-treated excitatory mouse model. DAEO administration significantly decreased locomotor activity at all doses except 0.000 04 mg per 400 μL of triethyl citrate. Both ascaridole and p-cymene were highly effective in decreasing locomotor activity of excited mice by more than 50%. In addition, ascaridole and p-cymene prolonged the pentobarbital-induced sleeping duration by 42% and 77%, respectively. These effects were antagonized by coadministration of gamma-aminobutyric acid (GABAA)-benzodiazepine receptor antagonist, flumazenil (3 mg/kg), indicating that the GABAergic system mediates the sedative effect. Finally, inhaled ascaridole and p-cymene had no negative effect on motor coordination, as observed during the Rota-rod test. Therefore, via activation of the GABAergic system, ascaridole and p-cymene mediate the sleep-promoting effect of DAEO. The results further extend the knowledge on their use as potential promising natural products for the management of sleep disorders and CNS-related ailments.

Published
2021
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5. Prenylated Benzophenones and Xanthones from Hypericum scabrum

Author

Tanaka, Naonobu, primary, Takaishi, Yoshihisa, additional, Shikishima, Yasuhiro, additional, Nakanishi, Yuka, additional, Bastow, Kenneth, additional, Lee, Kuo-Hsiung, additional, Honda, Gisho, additional, Ito, Michiho, additional, Takeda, Yoshio, additional, Kodzhimatov, Olimjon K., additional, and Ashurmetov, Ozodbek, additional

Published
2004
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6. New Stilbene Derivatives from Calligonum leucocladum

Author

Okasaka, Mamoru, primary, Takaishi, Yoshihisa, additional, Kogure, Kentarou, additional, Fukuzawa, Kenji, additional, Shibata, Hirohumi, additional, Higuti, Tomihiko, additional, Honda, Gisho, additional, Ito, Michiho, additional, Kodzhimatov, Olimjon K., additional, and Ashurmetov, Ozodbek, additional

Published
2004
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7. Sesquiterpenes from Ferula penninervis

Author

Shikishima, Yasuhiro, primary, Takaishi, Yoshihisa, additional, Honda, Gisho, additional, Ito, Michiho, additional, Takeda, Yoshio, additional, Tori, Motoo, additional, Takaoka, Shigeru, additional, Kodzhimatov, Olimjon K., additional, and Ashurmetov, Ozodbek, additional

Published
2002
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9. Polysulfide Derivatives from Ferula foetida

Author

Duan, Hongquan, primary, Takaishi, Yoshihisa, additional, Tori, Motoo, additional, Takaoka, Shigeru, additional, Honda, Gisho, additional, Ito, Michiho, additional, Takeda, Yoshio, additional, Kodzhimatov, Olimjon K., additional, Kodzhimatov, K., additional, and Ashurmetov, Ozodbek, additional

Published
2002
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10. An Unusual Sesquiterpene Derivative from Ferula kuhistanica

Author

Tamemoto, Kimiko, primary, Takaishi, Yoshihisa, additional, Kawazoe, Kazuyoshi, additional, Honda, Gisho, additional, Ito, Michiho, additional, Kiuchi, Fumiyuki, additional, Takeda, Yoshio, additional, Kodzhimatov, Olimjon K., additional, Ashurmetov, Ozodbek, additional, Shimizu, Katsuhide, additional, Nagasawa, Hideko, additional, Uto, Yoshihiro, additional, and Hori, Hitoshi, additional

Published
2002
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11. Benzoylphloroglucinol Derivatives from Hypericum scabrum

Author

Matsuhisa, Michiko, primary, Shikishima, Yasuhiro, additional, Takaishi, Yoshihisa, additional, Honda, Gisho, additional, Ito, Michiho, additional, Takeda, Yoshio, additional, Shibata, Hirohumi, additional, Higuti, Tomihiko, additional, Kodzhimatov, Olimjon K., additional, and Ashurmetov, Ozodbek, additional

Published
2002
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12. Sesquiterpenes and Monoterpenes from the Bark of Inula macrophylla

Author

Su, Bao-Ning, primary, Takaishi, Yoshihisa, additional, Yabuuchi, Tetsuya, additional, Kusumi, Takenori, additional, Tori, Motoo, additional, Takaoka, Shigeru, additional, Honda, Gisho, additional, Ito, Michiho, additional, Takeda, Yoshio, additional, Kodzhimatov, Olimjon K., additional, and Ashurmetov, Ozodbek, additional

Published
2001
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13. Sesquiterpene Lactones from the Roots of Ferula variaand Their Cytotoxic Activity

Author

Suzuki, Kyoko, Okasaka, Mamoru, Kashiwada, Yoshiki, Honda, Gisho, Ito, Michiho, Takeda, Yoshio, K. Kodzhimatov, Olimjon, Ashurmetov, Ozodbek, Sekiya, Michiko, Ikeshiro, Yasumasa, and Takaishi, Yoshihisa

Abstract

The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula variagave six new sesquiterpene lactones ( 1– 6) and five known sesquiterpenes ( 7– 11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1– 11were evaluated against selected human cancer cell lines. Compound 4showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.

Published
2007
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14. Role of Ascaridole and p -Cymene in the Sleep-Promoting Effects of Dysphania ambrosioides Essential Oil via the GABAergic System in a ddY Mouse Inhalation Model.

Author

Dougnon G and Ito M

Subjects
Animals, Cyclohexane Monoterpenes chemistry, Cymenes chemistry, Mice, Monoterpenes chemistry, Peroxides chemistry, Chenopodium ambrosioides chemistry, Cyclohexane Monoterpenes pharmacology, Cymenes pharmacology, Monoterpenes pharmacology, Oils, Volatile chemistry, Peroxides pharmacology, Plant Leaves chemistry, Sleep drug effects
Abstract

The essential oil obtained from Dysphania ambrosioides leaves (DAEO) has antifungal, antioxidant, and antimicrobial properties. This study investigated DAEO's chemical composition and its sleep-promoting effects via administration by inhalation in ddY mice. Ascaridole (35.5%) and p -cymene (47.2%) were the major components. To obtain insight into DAEO's effects on the central nervous system (CNS), ascaridole and p -cymene were evaluated for sedative activity by using the caffeine-treated excitatory mouse model. DAEO administration significantly decreased locomotor activity at all doses except 0.000 04 mg per 400 μL of triethyl citrate. Both ascaridole and p -cymene were highly effective in decreasing locomotor activity of excited mice by more than 50%. In addition, ascaridole and p -cymene prolonged the pentobarbital-induced sleeping duration by 42% and 77%, respectively. These effects were antagonized by coadministration of gamma-aminobutyric acid (GABA A )-benzodiazepine receptor antagonist, flumazenil (3 mg/kg), indicating that the GABAergic system mediates the sedative effect. Finally, inhaled ascaridole and p -cymene had no negative effect on motor coordination, as observed during the Rota-rod test. Therefore, via activation of the GABAergic system, ascaridole and p -cymene mediate the sleep-promoting effect of DAEO. The results further extend the knowledge on their use as potential promising natural products for the management of sleep disorders and CNS-related ailments.

Published
2021
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15. New icetexane and 20 norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi.

Author

Uchiyama N, Kiuchi F, Ito M, Honda G, Takeda Y, Khodzhimatov OK, and Ashurmetov OA

Subjects
Animals, Diterpenes chemistry, Diterpenes pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Trypanocidal Agents chemistry, Trypanocidal Agents pharmacology, Diterpenes isolation & purification, Lamiaceae chemistry, Plants, Medicinal chemistry, Trypanocidal Agents isolation & purification, Trypanosoma cruzi drug effects
Abstract

Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 micro M.

Published
2003
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