1. Trichothecrotocins D–L, Antifungal Agents from a Potato-Associated Trichothecium crotocinigenum
- Author
-
Hong-Lian Ai, Xian-Dong Zhang, Ji-Kai Liu, Fa-Lei Zhang, Zheng-Hui Li, Tao Feng, Hui-Xiang Yang, and Juan He
- Subjects
Pharmacology ,Antifungal ,biology ,010405 organic chemistry ,Chemistry ,Stereochemistry ,medicine.drug_class ,Organic Chemistry ,Trichothecene ,Pharmaceutical Science ,Fungus ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,Mic values ,Drug Discovery ,medicine ,Molecular Medicine ,Enantiomer - Abstract
Seven new merosesquiterpenoids, trichothecrotocins D-J (1-7), two new trichothecene sesquiterpenoids, trichothecrotocins K (12) and L (13), and six known compounds (8-11, 14, and 15), were isolated from a potato-associated fungus, Trichothecium crotocinigenum. Compounds 5 and 6 were racemates which were further separated as pure enantiomers. Structures together with absolute configurations were established by extensive spectroscopic analysis, as well as quantum chemistry calculations on ECD and optical rotations. Compounds 1-4 are rare meroterpenoids featuring a seco-phenyl group, while 1 and 2 possessed a novel 6-6/5 fused ring system. Compounds 1-4, 8, 11, and 12 showed antifungal activity against four plant pathogens with MIC values of 8-128 μg/mL. It is suggested that the meroterpenoids produced by T. crotocinigenum may play an important role in the antifungal property of the fungus, thereby protecting the host plant, i.e., potato.
- Published
- 2020
- Full Text
- View/download PDF