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Your search keyword '"Hironori Okamura"' showing total 3 results
Start Over Author "Hironori Okamura" Journal journal of natural products
3 results on '"Hironori Okamura"'

2. Total Synthesis and Structure Confirmation of trans-Anhydromevalonate-5-phosphate, a Key Biosynthetic Intermediate of the Archaeal Mevalonate Pathway

Author

Kohei Kitsuwa, Kai Saito, Hisashi Hemmi, Mutsumi Komeyama, Hironori Okamura, Yoko Yasuno, Tetsuro Shinada, and Atsushi Nakayama

Subjects
Pharmacology, chemistry.chemical_classification, biology, Chemistry, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Total synthesis, Cleavage (embryo), biology.organism_classification, Terpenoid, Analytical Chemistry, Enzyme, Complementary and alternative medicine, Dehydratase, Drug Discovery, Molecular Medicine, Aeropyrum pernix, Phosphorylation, Mevalonate pathway
Abstract

The mevalonate pathway is an upstream terpenoid biosynthetic route of terpenoids for providing the two five-carbon units, dimethylallyl diphosphate, and isopentenyl diphosphate. Recently, trans-anhydromevalonate-5-phosphate (tAHMP) was isolated as a new biosynthetic intermediate of the archaeal mevalonate pathway. In this study, we would like to report the first synthesis of tAHMP and its enzymatic transformation using one of the key enzymes, mevalonate-5-phosphate dehydratase from a hyperthermophilic archaeon, Aeropyrum pernix. Starting from methyl tetrolate, a Cu-catalyzed allylation provided an E-trisubstituted olefin in a stereoselective manner. The resulting E-olefin was transformed to tAHMP by cleavage of the olefin and phosphorylation. The structure of the synthetic tAHMP was unambiguously determined by NOESY analysis.

Published
2021

3. Total Synthesis and Structure Confirmation of

Author

Yoko, Yasuno, Atsushi, Nakayama, Kai, Saito, Kohei, Kitsuwa, Hironori, Okamura, Mutsumi, Komeyama, Hisashi, Hemmi, and Tetsuro, Shinada

Subjects
Hemiterpenes, Organophosphorus Compounds, Molecular Structure, Terpenes, Mevalonic Acid, Aeropyrum, Hydro-Lyases, Organophosphates
Abstract

The mevalonate pathway is an upstream terpenoid biosynthetic route of terpenoids for providing the two five-carbon units, dimethylallyl diphosphate, and isopentenyl diphosphate. Recently

Published
2021

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