Search

Your search keyword '"Eldridge, Gary R."' showing total 12 results
Start Over Author "Eldridge, Gary R." Journal journal of natural products
12 results on '"Eldridge, Gary R."'

3. Diterpenes from the Endangered Goldenrod Solidago shortii

Author

Williams, Russell B., primary, Du, Lin, additional, Norman, Vanessa L., additional, Goering, Matt G., additional, O’Neil-Johnson, Mark, additional, Woodbury, Scott, additional, Albrecht, Matthew A., additional, Powell, Douglas R., additional, Cichewicz, Robert H., additional, Eldridge, Gary R., additional, and Starks, Courtney M., additional

Published
2014
Full Text
View/download PDF

6. Isolation and Identification of the Novel Tubulin Polymerization Inhibitor Bifidenone

Author

Williams, Russell B., Martin, Steven M., Lawrence, Julie A., Norman, Vanessa L., O’Neil-Johnson, Mark, Eldridge, Gary R., and Starks, Courtney M.

Abstract

The pursuit of structurally novel compounds has led to the isolation of a series of neolignans (2–6), for which the structures have been determined from microgram quantities using microcryoprobe NMR technology. Compounds 2–6provided some unexpectedly clear structure–activity relationship data, with compound 2demonstrating significantly more potency in the in vitro cytotoxicity assay than the other analogues. Further screening found that compound 2induces apoptosis with activation of caspase 3/7. The NCI Compare algorithm suggested that compound 2acts through the inhibition of tubulin/microtubule dynamics. Compound 2was confirmed to be a tubulin polymerization inhibitor that binds directly to tubulin.

Published
2017
Full Text
View/download PDF

10. Bacterial Biofilm Inhibitors from Diospyros dendo

Author

Hu, Jin-Feng, primary, Garo, Eliane, additional, Goering, Matt G., additional, Pasmore, Mark, additional, Yoo, Hye-Dong, additional, Esser, Tim, additional, Sestrich, Jennifer, additional, Cremin, Peadar A., additional, Hough, Grayson W., additional, Perrone, Peter, additional, Lee, Yin-Shi L., additional, Le, Ngoc-Tram, additional, O'Neil-Johnson, Mark, additional, Costerton, John W., additional, and Eldridge, Gary R., additional

Published
2006
Full Text
View/download PDF

11. Suaveolindole, a New Mass-Limited Antibacterial Indolosesquiterpene from Greenwayodendron suaveolens Obtained via High-Throughput Natural Products Chemistry Methods

Author

Yoo, Hye-Dong, primary, Cremin, Peadar A., additional, Zeng, Lu, additional, Garo, Eliane, additional, Williams, Caroline T., additional, Lee, Chris M., additional, Goering, Matt G., additional, O'Neil-Johnson, Mark, additional, Eldridge, Gary R., additional, and Hu, Jin-Feng, additional

Published
2005
Full Text
View/download PDF

12. Antibiotic Indole Sesquiterpene Alkaloid from Greenwayodendron suaveolenswith a New Natural Product Framework

Author

Williams, Russell B., Hu, Jin-Feng, Olson, Krista M., Norman, Vanessa L., Goering, Matt G., O’Neil-Johnson, Mark, Eldridge, Gary R., and Starks, Courtney M.

Abstract

High-throughput natural products chemistry methods have led to the isolation of three new (1−3) and two known indole sesquiterpene alkaloids (4, 5) from Greenwayodendron suaveolens. Their structures were determined using CapNMR and MS. Pentacyclindole (1) was determined to possess a new natural product framework. Pentacyclindole (1) and polyalthenol (4) showed activity against clinical isolates of Staphylococcus aureuswith polyalthenol (4) demonstrating a MIC90of 4 μg/mL.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results