1. Cerebrosides and Tocopherol Trimers from the Seeds of Euryale ferox
- Author
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Lie-Ching Row, Jiau-Ching Ho, and Chiu-Ming Chen
- Subjects
Stereochemistry ,Tocopherols ,Pharmaceutical Science ,Brine shrimp ,Pharmacognosy ,Analytical Chemistry ,Cerebrosides ,Drug Discovery ,Animals ,Tocopherol ,Pharmacology ,chemistry.chemical_classification ,Plants, Medicinal ,Molecular Structure ,biology ,Nymphaeaceae ,Chemistry ,Organic Chemistry ,Glycoside ,biology.organism_classification ,Cerebroside ,Complementary and alternative medicine ,Seeds ,Molecular Medicine ,Artemia ,Artemia salina ,Two-dimensional nuclear magnetic resonance spectroscopy ,Euryale ferox ,Drugs, Chinese Herbal - Abstract
Two new cerebrosides, ferocerebrosides A (1) [(2S,3R,4E,8E,2'R)-1-O-(beta-glucopyranosyl)-N-(2'-hydroxydocosanoyl)-4,8-sphingadienine] and B (2) [(2S,3R,4E,8E,2'R)-1-O-(beta-glucopyranosyl)-N-(2'-hydroxytetracosanoyl)-4,8-sphingadienine], two new tocopherol trimers, ferotocotrimers C (5) and D (6), and two known tocopherol trimers, IVb (3) and IVa (4), were isolated from the seeds of Euryale ferox. Their structures were determined on the basis of spectroscopic data, especially 1D and 2D NMR experiments. Compounds 1 and 2 showed cytotoxicity in the brine shrimp lethality bioassay, with LC50 values of 0.17 and 0.20 mM, respectively.
- Published
- 2007
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