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Chemical analysis of the chloroform extract of the aerial parts of the Algerian plant Pulicaria undulataexhibiting anti-inflammatory activity resulted in the isolation of 10 new humulene sesquiterpenoids, 1–10, belonging to the asteriscunolide family of compounds. The structure and relative configuration have been defined by NMR data, whereas the absolute configuration has been established by ECD analysis. Compounds 1–10include enantiomers of the known asteriscunolides A–D and tetrahydroasteriscunolide previously reported from the genera Asteriscusand Nauplius. Compounds 1and 10showed in vitro anti-inflammatory activity by inhibiting heat-induced albumin denaturation with IC50values of 23.76 and 220.42 μM.