1. Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius
- Author
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Maribel G. Nonato, Thomas Edison E. dela Cruz, Noriyuki Kogure, Scott G. Franzblau, Hiromitsu Takayama, Mariko Kitajima, Melfei E. Bungihan, and Mario A. Tan
- Subjects
Magnetic Resonance Spectroscopy ,Strain (chemistry) ,biology ,Ascomycota ,Molecular Structure ,Antitubercular Agents ,Virulence ,Mycobacterium tuberculosis ,Endophytic fungus ,biology.organism_classification ,Plant use of endophytic fungi in defense ,Microbiology ,Plant Leaves ,Botany ,Pandanus amaryllifolius ,Molecular Medicine ,Pandanaceae - Abstract
Two new benzopyranones, diaportheone A (1) and B (2), were obtained via bioassay-guided isolation of the secondary metabolites from the endophytic fungus Diaporthe sp. P133 isolated from Pandanus amaryllifolius leaves. Their structures were determined from spectral analysis including mass spectrometry, 1D and 2D nuclear magnetic resonance. Both 1 and 2 inhibited the growth of the virulent strain of Mycobacterium tuberculosis H(37)Rv with minimum inhibitory concentrations of 100.9 and 3.5 μM, respectively.
- Published
- 2010