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Start Over Author "Ding, Liqin" Journal journal of natural medicines
3 results on '"Ding, Liqin"'

3. Isolation, structural elucidation and in vitro hepatoprotective activity of flavonoids from Glycyrrhiza uralensis

Author

Cao Shijie, Hongmin Zhang, Ding Liqin, Feng Qiu, Wei Li, Yingjie Sun, Hongfeng Kan, Benke Jiang, Kazuo Koike, and Ming Cheng

Subjects
Pterocarpans, Flavonoid, 01 natural sciences, Flavones, Plant Roots, chemistry.chemical_compound, Chalcones, Coumarins, Cell Line, Tumor, Glycyrrhiza, Humans, Glycyrrhiza uralensis, Glycosides, chemistry.chemical_classification, Flavonoids, Traditional medicine, biology, 010405 organic chemistry, Glycoside, Dihydrochalcone, Hep G2 Cells, Isoflavones, biology.organism_classification, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Hepg2 cells, Flavanones, Molecular Medicine
Abstract

Two new flavonoid glycosides, 2′,4′-dihydroxydihydrochalcone-4-O-β-d-glucopyranoside (1) and medicarpin-3-O-β-d-apiofuranosyl (1 → 2)-β-d-glucopyranoside (2), together with 34 known flavonoids were isolated from the 75% EtOH extract of the dried roots of Glycyrrhiza uralensis Fisch. Their structures were elucidated on the basis of spectroscopic analyses. The flavonoids were classified into ten sub-types, namely, dihydrochalcone (1), pterocarpans (2–4), flavones (5–6), flavanones (7–11), chalcones (12–15), retro-chalcones (16–18), isoflavans (19–21), isoflavones (22–28), 3-arylcoumarins (29–30), and coumestans (31–36). The isolated flavonoids were evaluated for in vitro hepatoprotective activity against d-galactosamine-induced toxicity in human hepatoma HepG2 cells.

Published
2019

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